ArticleBMC cancer2025
Three-dimensional turbo-spin-echo amide proton transfer-weighted and intravoxel incoherent motion imaging mri for triple-negative breast cancer: a comparison with molecular subtypes and histological grades.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Amide proton transfer-weighted magnetic resonance imaging for the diagnosis of triple-negative breast cancer: a comparative study with diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Comparison of postprocessing metrics in multimetabolic APT-weighted CEST and 2-deoxy-D-glucose-CEST-MRI for differentiating breast cancer subtypes in a murine model.European radiology experimental · 2026Article
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13 authors.
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Abstract
objectiveTo investigate associations between breast cancer molecular subtype and intravoxel incoherent motion imaging (IVIM) and amide proton transfer-weighted (APTw).
methodsThis prospective study involved 264 patients with suspected breast tumors who underwent both breast APTw and IVIM MRI. The maximum diameter of the tumor (Dmax), APT value, apparent diffusion coefficient (ADC), diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) values along with histological subtype, grade, and prognostic factors (Ki-67, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), were compared. APT values about biological subtypes, Ki-67 labeling index, and nuclear grades (NGs) were further analyzed.
resultsA total of 205 participants (mean age, 53 years, range 29-80) were included in the evaluation. The triple-negative breast cancer (TNBC) cancers showed significantly higher D* values than the Luminal B cancers (P = 0.002), while there was no difference in Dmax, ADC, D, and APT (P = 0.068,0.318,0.432,0.089). The TN-type cancers showed significantly higher APT values than the HER2-type cancers (P = 0.002). The area under the curve (AUC) obtained from APTw, IVIM, and Dmax was 0.874. The APT had a moderate positive correlation with the unclear grade (r = 0.473, P < 0.001), and the D* had a weak positive correlation with the Ki-67 labeling index(r = 0.160, P = 0.022).
conclusionThe TN subtype of breast cancer is associated with APT value and D* from IVIM. The APTw may be a promising method for predicting TNBC molecular subtypes.
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