ArticleBMC genomics2025
GWAS and transcriptome analyses unravel ZmGRAS15 regulates drought tolerance and root elongation in maize.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genome-Wide and GWAS Dissection of Maize Fibrillin Genes Reveals Plastid Regulators of Drought and Salt Stress Tolerance.Current issues in molecular biology · 2026Article
- Molecular Mechanisms in Responses to Combined Stresses in Strawberry.Current issues in molecular biology · 2026Review
- Integrating gene expression and morphological traits for drought stress adaptation in maize hybrids.Scientific reports · 2026Article
- Genome-wide association study reveals the genetic architecture of drought tolerance in maize using yield-based resistance indices and transcriptomic evidence.The plant genome · 2026Article
- Multi-locus GWAS uncovers favorable alleles and candidate genes underlying water stress response in chrysanthemum.BMC plant biology · 2026Article
- A genome-wide association study unveils the genetic architecture of morphological and biomass partitioning traits in maize under iron-deficient stress.Scientific reports · 2026Article
- Article
- Genome-wide association study and functional validation ofHorticulture research · 2026Article
- Review
- Genome-wide and co-expression network dissection ofFrontiers in plant science · 2026Article
- Comprehensive identification ofFrontiers in plant science · 2026Article
- Bioinformatics in crop research: using genomic data for crop improvement.Frontiers in plant science · 2026Review
- Genome Editing Enhanced Abiotic Stress ToleranceIn Cereal Crops.Functional & integrative genomics · 2025Review
- A multi-locus genome-wide association study uncovers candidate genes for alkali tolerance in maize (Zea Mays L.) seedlings.BMC genomics · 2025Article
- Genome-wide profiling of GRAS genes in flax (GM crops & food · 2025Article
- Unearthing the hidden organ: vital role of the root in drought tolerance of plants.Plant molecular biology · 2025Review
- Identification of candidate genes and proteins for tasseling stage drought tolerance through integrated transcriptomic and proteomic analysis approach in maize.BMC plant biology · 2025Article
- Resilience of Maize to Environmental Stress: Insights into Drought and Heat Tolerance.International journal of molecular sciences · 2025Review
- Comparative transcriptome and metabolome profiling unveil genotype-specific strategies for drought tolerance in cotton.Frontiers in plant science · 2025Article
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Authors and funding
10 authors.
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Abstract
backgroundDrought is a major abiotic stress affecting maize development and growth. Unravelling the molecular mechanisms underlying maize drought tolerance and enhancing the drought tolerance of maize is of great importance. However, due to the complexity of the maize genome and the multiplicity of drought tolerance mechanisms, identifying the genetic effects of drought tolerance remains great challenging.
resultsUsing a mixed linear model (MLM) based on 362 maize inbred lines, we identified 40 associated loci and 150 candidate genes associated with survival rates. Concurrently, transcriptome analysis was conducted for five drought - tolerant and five drought - sensitive lines under Well-Watered (WW) and Water-Stressed (WS) conditions. Additionally, through co-expression network analysis (WGCNA), we identified five modules significantly associated with the leaf relative water content (RWC) under drought treatment. By integrating the results of GWAS, DEGs, and WGCNA, four candidate genes (Zm00001d006947, Zm00001d038753, Zm00001d003429 and Zm00001d003553) significantly associated with survival rate were successfully identified. Among them, ZmGRAS15 (Zm00001d003553), a GRAS transcription factor considered as a key hub gene, was selected for further functional validation. The overexpression of ZmGRAS15 in maize could significantly enhance drought tolerance through regulating primary root length at the seedling stage.
conclusionThis study provides valuable information for understanding the genetic basis of drought tolerance and gene resources for maize drought tolerance breeding.
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