Evidence map›Paper›PMID 40082787›Full record

ArticleBMC cardiovascular disorders2025

Association between urinary sodium excretion and all-cause mortality: a cohort study in a Chinese community-based population.

Haotai Xie, Xinyan Wen, Fangfang Fan, Jia Jia, Yong Huo, Yanjun Gong, Yan Zhang

Abstract read
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haotai Xie *Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Xinyan Wen *Department of Cardiology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
Fangfang FanDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Jia JiaDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Yanjun GongDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China. gongyanjun111@163.com.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China. drzhy1108@163.com.

Funding

National Key Research and Development Program of China 2021YFC2500503
6 · The paper itself

Abstract

backgroundThe association between sodium intake and mortality risk in the general population remains controversial. We aimed to explore the association between sodium intake and all-cause mortality in a Chinese community-based population.

methodsA total of 6510 individuals from a Chinese community-based cohort were enrolled. 24-hour urinary sodium excretion was estimated using the Kawasaki formula. Cox proportional hazards models were used to determine the association of estimated urinary sodium excretion and spot urinary sodium with all-cause mortality.

resultsWith a mean follow-up of 3.13 years, 65 participants (1.0%) experienced all-cause mortality. The association between estimated urinary sodium excretion and all-cause mortality appeared to be J-shaped (P for non-linearity = 0.009). Individuals were grouped in quartiles according to estimated urinary sodium excretion and spot urinary sodium. After adjusting for risk factors, the fourth quartile of estimated urinary sodium excretion (> 5.75 g/day) was associated with an increased risk of mortality compared to the second quartile (3.90 to 4.76 g/day) (hazard ratio 2.94; 95% confidence interval, 1.27-6.83). Subgroup analyses revealed that current drinking status (P for interaction = 0.005) may serve as a potential modifying factor influencing the association between estimated urinary sodium excretion and all-cause mortality. There was no association between spot urinary sodium and all-cause mortality.

conclusionsHigher estimated urinary sodium excretion significantly increased all-cause mortality risk compared to moderate levels. Extremely low estimated urinary sodium excretion showed a similar trend. It is important for individuals with high sodium intake to reduce consumption to lower mortality risk. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

MortalityRenal EliminationSodium, DietaryAdultAgedBiomarkersChinaEast Asian PeopleFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRisk AssessmentRisk FactorsBiomarkersSodium, DietaryMortalitySodium intakeSpot urinary sodiumUrinary sodium excretion

Identifiers

PMID40082787
PMCPMC11905439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.