ArticleScientific reports2025
Increased bronchopulmonary dysplasia along with decreased mortality in extremely preterm infants.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elevated HMGB1 Levels in Neonates With Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Canadian respiratory journal · 2026Pooled it
- Reframing Risk: Intubation Time Outweighs Tracheostomy in Predicting Neurodevelopment in Severe BPD.The Laryngoscope · 2026Article
- Pattern and Predictors of Bronchopulmonary Dysplasia in Preterm Infants in New South Wales, Australia: A Population-Based Cohort Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Outcomes at 21 weeks' gestation: a case series with neurodevelopmental follow-up.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Threshold Effect of Cumulative Postnatal Corticosteroid Dose on Long-Term Outcomes in Extremely Preterm Infants.Journal of clinical medicine · 2026Article
- Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Expression and significance of miR-9-5p and GCH1 in neonates with bronchopulmonary dysplasia.Translational pediatrics · 2026Article
- IncreasedbioRxiv : the preprint server for biology · 2026Article
- Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.American journal of physiology. Cell physiology · 2026Article
- Optimal postnatal corticosteroid regimens to prevent bronchopulmonary dysplasia with minimal adverse effects.Clinical and experimental pediatrics · 2026Article
- Impact of birth weight on long-term growth and development in children: evidence from a nationwide cohort study.BMC pediatrics · 2026Article
- Early prediction of bronchopulmonary dysplasia using new classification in high-risk preterm infants.Clinical and experimental pediatrics · 2026Article
- Outcomes of children after initiation of home mechanical ventilation via tracheostomy: a single center retrospective study.BMC pulmonary medicine · 2026Article
- Endotracheal Intubation in Early Life and Its Association with Mental Health Disorders from Childhood to Adolescence: A National Longitudinal Cohort Study up to Age 18.Journal of clinical medicine · 2026Article
- Variations in survival outcomes of infants born at 22-23 weeks' gestation by neonatal intensive care quality level in Korea.Scientific reports · 2026Article
- A three-factor nomogram predicts the use of invasive mechanical ventilation within 72 h in preterm infants.Frontiers in medicine · 2026Article
- The molecular mechanisms of gas signaling molecules in bronchopulmonary dysplasia related lung injury.Frontiers in cell and developmental biology · 2026Review
- The Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Real-world use of hydrocortisone and dexamethasone in the prevention and treatment of bronchopulmonary dysplasia in preterm infants <32 weeks: a nine-year cohort study.Frontiers in pediatrics · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Advances in neonatal intensive care have significantly reduced mortality and morbidity in extremely preterm infants (EPIs). However, the incidence of bronchopulmonary dysplasia (BPD) remains similar or is even increasing. This study examines trends in mortality, BPD, and composite outcome of BPD or mortality among EPIs in Korea. We analyzed data from the Korean Neonatal Network, a nationwide cohort of preterm infants in Korea. EPIs with gestational ages of 23-27 weeks born between 2014 and 2021 were included. Among 4,450 survivors (mean gestational age 25.7 ± 1.2 weeks, mean birth weight 870.7 ± 194.2 g), the incidence of BPD rose from 51.2 to 62.7% (P < 0.001), while mortality declined from 28.3 to 19.5% (P < 0.001). The composite outcome of BPD or mortality also increased, from 63.6 to 66.9% (P = 0.006). The duration of invasive ventilation, rates of endotracheal intubation at birth, and intubation for surfactant administration decreased, whereas the duration of non-invasive ventilation and overall ventilatory support increased. Despite decreasing mortality, the incidence of BPD among survivors and composite outcome of BPD or mortality increased, potentially driven by longer ventilatory support. This suggests a trade-off where improved survival rates in EPIs lead to a higher incidence of BPD.
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