ArticleSpinal cord2025
Histology of neurogenic heterotopic ossification and comparison with its radiological expression in acute spinal cord injured patients.
Article in Spinal cord, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Neurogenic heterotopic ossification: from molecular mechanisms to clinical treatment.Journal of orthopaedic translation · 2026Review
- Cytokine array analyses and osteogenic potential of plasma from patients with traumatic brain-/spinal cord injury: predictive markers of heterotopic ossification?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
STUDY
designClinical prospective study.
objectivesTo histologically examine puncture biopsies of early neurogenic heterotopic ossification (NHO) in spinal cord injured individuals.
settingUniversity of Bochum, Germany.
methodsAfter acute spinal trauma, participants underwent a sonographic examination of the hip joints and a routine laboratory examination. Magnetic resonance imaging (MRI) or computed tomography (CT) of the pelvis was performed if there were clinical and laboratory signs of NHO and sonographic evidence of edema and/or calcifications in the tissue around the hip joint. If NHO were detected, tissue was obtained and preserved for histological examination from the involved tissue around the hip joint affected by NHO and from an unaffected calf as control. Nine participants with a complete spinal cord lesion American Spinal Injury Association Impairment Scale (AIS) grade A and evidence of an acute NHO in the hip joint muscles were recruited for the study.
resultsIn all sonographic examinations of the hip joint, edematous changes could be detected. In one case, calcifications were detected sonographically. In MRI/CT in six participants, ossification could already be detected. All histological specimens from the NHO-affected gluteal region showed varying degrees of tissue deformation. The unaffected reference samples showed regular muscular structure microscopically.
conclusionsIt was possible to show and compare histological changes in NHO-affected tissue with MRI/CT imaging, depending on the stage of NHO.
trial registrationDRKS, DRKS00034049. Registered 12 April 2024 - Retrospectively registered, https://www.drks.de/DRKS00034049 .
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