Evidence map›Paper›PMID 40082653›Full record

ArticleNPJ digital medicine2025

Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations.

Yi-Han Sheu, Jaak Simm, Bo Wang, Hyunjoon Lee, Jordan W Smoller

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yi-Han Sheu *Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA. ysheu@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2767-0851
Jaak Simm *Department of Electrical Engineering, KU Leuven, Leuven, Belgium.
Bo Wang *Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Hyunjoon LeeCenter for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Jordan W SmollerCenter for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334

Funding

Project-001P50MH129699 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Andrea S Foulkes · 2023 to 2026
$16.6M
Improved multifactorial prediction of suicidal behavior through integration of multiple datasetsR01MH117599 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI REIS, BEN Y, SMOLLER, JORDAN W · 2018 to 2021
$2.1M
NIMH NIH HHS P50 MH129699NIMH NIH HHS R01 MH117599U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) NIMH R01 MH117599
6 · The paper itself

Abstract

Current clinician-based and automated risk assessment methods treat the risk of suicide-related behaviors (SRBs) as static, while in actual clinical practice, SRB risk fluctuates over time. Here, we develop two closely related model classes, Event-GRU-ODE and Event-GRU-Discretized, that can predict the dynamic risk of events as a continuous trajectory across future time points, even without new observations, while updating these estimates as new data become available. Models were trained and validated for SRB prediction using a large electronic health record database. Both models demonstrated high discrimination (e.g., Event-GRU-ODE AUROC = 0.93, AUPRC = 0.10, relative risk = 13.4 at 95% specificity in a low-prevalence [0.15%] general cohort with a 1.5-year prediction window). This work provides an initial step toward developing novel suicide prevention strategies based on dynamic changes in risk.

Identifiers

PMID40082653
PMCPMC11906764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.