SynthesisEvidence-based dentistry2025
Grading the strength and certainty of the scientific evidence of the bidirectional association between periodontitis and noncommunicable diseases: an umbrella review.
Synthesis in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Grading the evidence for the association between periodontal disease and chronic non-communicable diseases: an umbrella review of meta-analyses of observational studies.BMC oral health · 2026Pooled it
- Guidance for Grading the Evidence in Quantitative Umbrella Reviews.Journal of evidence-based medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeriodontitis and various noncommunicable diseases (NCDs) have been proposed to have a bidirectional relationship. The purpose of this umbrella review is (1) to synthesize the evidence and (2) to grade the strength and certainty of the scientific evidence regarding the bidirectional association between periodontitis and NCDs. DATA SOURCES: Electronic databases were systematically searched from January 2021 and July 2024; MEDLINE (via PubMed), Embase and SciELO. DATA SELECTION AND EXTRACTION: Potential epidemiologic systematic reviews with meta-analysis that studied the bidirectional association between periodontitis and NCDs were identified by two independent reviewers and filtered by title and abstract according to the selection criteria. The strength and the quality and certainty of the evidence was assessed according to the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guide. 561,554 potential results were identified. After removing duplicates and excluding records deemed ineligible by automated filters, 450 results were screened by title and abstract. This process led to 41 records being appraised in full-text. Of these, 17 were further excluded leaving a total of 24 systematic reviews that met the inclusion criteria. DATA SYNTHESIS: 24 systematic reviews with a total of 32 NCDs were appraised and consolidated. Risk of bias assessment indicated that 21 systematic reviews (87.5%) demonstrated low bias (high quality), 2 had medium bias, and 1 exhibited high bias (low quality). Key issues identified included the formulation of explicit research questions, critical appraisal, data extraction, and publication bias. The association between periodontitis and NCDs was strong in 1 systematic review, moderate in 8, weak in 10 and absent in 7 systematic reviews. The strength of the association between NCDs and periodontitis was moderate in 6 systematic reviews and weak in 3 systematic reviews. The size of the reported effect (odds ratio/risk ratio/hazard ratio) was broader with increasing strength. Although data supports the association between periodontitis and some NCDs, and to a lesser extent between some NCDs and periodontitis, the certainty of the evidence was classified as low to very low.
conclusionsThere is some data that, with varying degrees of association and low to very low certainty, provide evidence that periodontitis may be a potential risk factor for some NCDs and vice versa.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.