Evidence map›Paper›PMID 40082634›Full record

ArticleScientific reports2025

Clinically available predictors of obstructive sleep apnoea requiring treatment in type 2 diabetes patients in primary care.

Jonas Agholme, Kim Ahtola, Ebba Toll, Carl-Johan Carlhäll, Pontus Henriksson, Stergios Kechagias, Peter Lundberg, Patrik Nasr, Oleg Sysoev, Magnus Wijkman and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonas AgholmeDepartment of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden.
Kim AhtolaDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Ebba TollDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Carl-Johan CarlhällDepartment of Clinical Physiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Pontus HenrikssonDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Stergios KechagiasDepartment of Gastroenterology and Hepatology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Peter LundbergCenter for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Patrik NasrDepartment of Gastroenterology and Hepatology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Oleg SysoevDivision of Statistics and Machine Learning, Department of Computer and Information Science, Linköping University, Linköping, Sweden.
Magnus WijkmanDepartment of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden.
Mattias EkstedtDepartment of Gastroenterology and Hepatology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Martin UlanderDepartment of Clinical Neurophysiology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Fredrik IredahlWallenberg Center for Molecular Medicine, Linköping University, Linköping, Sweden. fredrik.iredahl@liu.se.ORCID http://orcid.org/0000-0002-4245-7565

Funding

ALF RÖ-938301Lions research fund RÖ-965260
6 · The paper itself

Abstract

Obstructive sleep apnoea is a common yet frequently underdiagnosed condition in patients with type 2 diabetes, particularly in primary care. Early detection is important, as untreated sleep apnoea may contribute to worsened metabolic control and increased cardiovascular risk. This study evaluated 164 patients with type 2 diabetes and found that 75% had obstructive sleep apnoea, with 31% requiring treatment for moderate to severe cases. Predicting obstructive sleep apnoea for which medical treatment is indicated (i.e., moderate to severe OSA) proved challenging, as typical clinical symptoms and most other readily available clinical parameters proved to be unreliable indicators. However, central fat distribution, indicated by a higher waist-to-hip ratio (odds ratio 3.31, 95% confidence interval 1.91-6.25, p = 0.0032), and the presence of albuminuria (odds ratio 7.46, 95% confidence interval 1.99-27.89, p = 0.0244), emerged as significant predictors, with albuminuria representing a novel finding. Screening tools such as the STOP-Bang questionnaire had limited predictive accuracy. These findings highlight the importance of targeted screening in patients with type 2 diabetes, particularly those with central fat distribution or albuminuria, to reduce underdiagnosis and potentially improve treatment outcomes.

Indexed as

Diabetes Mellitus, Type 2Sleep Apnea, ObstructiveAgedAlbuminuriaFemaleHumansMaleMiddle AgedPrimary Health CareRisk FactorsWaist-Hip RatioAlbuminuriaDiagnostic accuracyEpworth sleepiness scalePittsburgh sleep quality indexScreeningSTOP-Bang

Identifiers

PMID40082634
PMCPMC11906869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.