ArticleScientific reports2025
Phenylacetylcarbinol biotransformation by disrupted yeast cells using ultrasonic treatment in conjunction with a dipropylene glycol mediated biphasic emulsion system.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biotransformation of a pharmaceutical precursor, phenylacetylcarbinol (PAC), could be achieved by frozen-thawed Candida tropicalis whole cells (FT-WHC). The treatment of FT-WHC, which contained intracellular pyruvate decarboxylase (PDC) enzyme, using high-power ultrasonication with varying amplitudes were compared with glass bead attrition (GBA) as well as control for the release of PDC. Ultrasonication at 20% amplitude (Ult20) proved to be the most effective, resulting in the highest volumetric and specific PDC activities of 0.210 ± 0.004 U/mL and 0.335 ± 0.033 U/mg protein, respectively. Disrupted FT-WHC using Ult20 exhibited a statistically significant (p ≤ 0.05) higher initial PAC production rate (3.26 ± 0.04 mM). The comparison of three organic phases, namely, vegetable oil (Vg-Oil), Vg-Oil + dipropylene glycol (DPG), and octanol in the two-phase emulsion system for PAC biotransformation revealed the highest statistically significant (p ≤ 0.05) overall PAC concentration of 28.9 ± 0.1 mM in Vg-Oil + DPG system. The novel addition of DPG helped facilitating the partitioning of PAC into aqueous phase, stabilizing specific PDC activity, and specific PAC productivity in combination with ultrasonication treatment.
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