Evidence map›Paper›PMID 40082516›Full record

ArticleScientific reports2025

Toward a high-throughput in vitro model for estimating vitreous humor permeability of topically applied drugs.

Anna Vincze, Eszter Simon, Gábor Koplányi, József Gergely Stankovits, Diána Balogh-Weiser, Benjámin Gyarmati, Zoltán Zsolt Nagy, György T Balogh

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna VinczeDepartment of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 9, Budapest, H-1092, Hungary. vincze.anna@semmelweis.hu.
Eszter SimonDepartment of Electronics Technology, Faculty of Electrical Engineering and Informatics, Budapest University of Technology and Economics, Műegyetem Quay 3, Budapest, H-1111, Hungary.
Gábor KoplányiDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Quay 3, Budapest, H-1111, Hungary.
József Gergely StankovitsDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Quay 3, Budapest, H-1111, Hungary.
Diána Balogh-WeiserDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Quay 3, Budapest, H-1111, Hungary.
Benjámin GyarmatiDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem Quay 3, Budapest, H-1111, Hungary.
Zoltán Zsolt NagyDepartment of Ophthalmology, Semmelweis University, Mária Street 39, Budapest, H-1085, Hungary.
György T BaloghDepartment of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre Street 9, Budapest, H-1092, Hungary. balogh.gyorgy.tibor@semmelweis.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vitreous humor of the eye presents a crucial target for posterior segment therapy due to its proximity to the retina and relatively easy accessibility. Although intravitreous injections have long been the primary method for treating posterior segment disorders, recent successes in non-invasive topical treatments have led to the exploration of alternative administration routes. The objective of our study is to establish a platform for a Parallel Artificial Membrane Permeability Assay (PAMPA) model that mimics the posterior segment, modelling the permeation process of compounds applied topically on the eye. The study demonstrates the acceptor-phase effects of sodium hyaluronate and agar on passive permeability, while applying a previously published vitreous humor-mimetic material. Physicochemical similarities of the acceptor phase media and freshly excised porcine vitreous humor further support the applicability of the mimetic material, based on viscosity and zeta potential measurement. As a result, a new concept is introduced for measuring posterior segment permeability, with potential for future high throughput screening applications.

Indexed as

High-Throughput Screening AssaysVitreous BodyAdministration, TopicalAnimalsHyaluronic AcidMembranes, ArtificialModels, BiologicalPermeabilitySwineHyaluronic AcidMembranes, ArtificialIn vitro permeability modelOcular permeabilityPAMPAPosterior segment of the eyeSodium hyaluronateVitreous humorVitreous substitutes

Identifiers

PMID40082516
PMCPMC11906762

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.