Evidence map›Paper›PMID 40082490›Full record

ArticleScientific reports2025

Early-life gut microbiome is associated with behavioral disorders in the Rio birth cohort.

Nathalia Ferrazzo Naspolini, Ana Paula Natividade, Carmen Ildes Froes Asmus, Josino Costa Moreira, Maria Gloria Dominguez-Bello, Armando Meyer

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathalia Ferrazzo NaspoliniOswaldo Cruz Foundation, National School of Public Health Sergio Arouca, Rio de Janeiro, Brazil. nfnaspolini@gmail.com.
Ana Paula NatividadeOswaldo Cruz Foundation, National School of Public Health Sergio Arouca, Rio de Janeiro, Brazil.
Carmen Ildes Froes AsmusPublic Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Josino Costa MoreiraPublic Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Maria Gloria Dominguez-BelloDepartment of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ, USA.
Armando MeyerPublic Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence has been linking changes in the early-life gut microbiome and neurodevelopmental outcomes. The founder bacteria that first colonize the infant's gut determine the microbial succession that signals host tissues and impact development including the brain. Here we investigated the association between the meconium microbiome and neurobehavior. To this end, we surveyed the 16S rRNA gene on meconium samples and assessed behavioral outcomes at six-months of age by the Denver Developmental Screening Test II (DDST-II). Among the four behavioral domains investigated, the personal-social domain was associated with significant differences in meconium bacterial beta diversity (unweighted UniFrac; R

Indexed as

Gastrointestinal MicrobiomeBacteriaBirth CohortBrazilFemaleHumansInfantInfant, NewbornMaleMeconiumRNA, Ribosomal, 16SRNA, Ribosomal, 16SEarly-life microbiomeFounder microbesInfant neurodevelopmentNeurodevelopmental screeningRuminococcaceae

Identifiers

PMID40082490
PMCPMC11906608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.