Evidence map›Paper›PMID 40082460›Full record

Articlenpj aging2025

The role of inhibitory and excitatory neurometabolites in age-related differences in action selection.

Geraldine Rodríguez-Nieto, Amirhossein Rasooli, Hong Li, Stefan Sunaert, Dante Mantini, Mark Mikkelsen, Richard A E Edden, Sima Chalavi, Stephan P Swinnen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. GABA and Glx Distinctively Predict Motor Learning and Retention in Young and Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Geraldine Rodríguez-Nieto *Movement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Amirhossein Rasooli *Movement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Hong LiMovement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Stefan SunaertKU Leuven, Department of Imaging and Pathology, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Dante MantiniMovement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Mark MikkelsenDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sima ChalaviMovement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.
Stephan P SwinnenMovement Control and Neuroplasticity Research Group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium. stephan.swinnen@kuleuven.be.

Funding

China Scholarship Council (CSC) 201906170063Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G089818N
6 · The paper itself

Abstract

Aging is accompanied by changes in the level of neurometabolites. However, their role in vital behavioral functions is still unclear. We aimed to explore the impact of aging on the neurochemical mechanisms underlying action selection. Young (YA) (n = 25) and older adults (OA) (n = 26) performed a simple (SRT) and a choice (CRT) reaction time tasks. Magnetic resonance spectroscopy was utilized to track task-induced modulations in GABA and glutamate in the sensorimotor cortex (SM1) and dorsolateral prefrontal cortex (dlPFC). Results showed that (i) SM1 Glx levels were higher during the SRT in the full sample, (ii) Glx modulation in the dlPFC predicted better behavioral performance in the SRT only in YA, and iii) a task-induced increase in GABA and Glx in the dlPFC was related to action selection learning in the full sample. Our findings highlight an important role of neurometabolic modulation during action selection and learning.

Identifiers

PMID40082460
PMCPMC11906731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.