Evidence map›Paper›PMID 40082431›Full record

ArticleNature communications2025

Epidemiology and transmission dynamics of multidrug-resistant organisms in nursing homes within the United States.

Lona Mody, Kristen E Gibson, Marco Cassone, Ganga Vijayasiri, Tasmine Clement, Evan Snitkin, Sanjay Saint, Sarah L Krein, Mary R Janevic, Jessica Thiel and 12 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lona ModyDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. lonamody@med.umich.edu.ORCID http://orcid.org/0000-0002-0260-8007
Kristen E GibsonDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5648-5209
Marco CassoneDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Ganga VijayasiriDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Tasmine ClementDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Evan SnitkinDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Sanjay SaintDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Sarah L KreinDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Mary R JanevicDepartment of Health Behavior and Health Equity, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Jessica ThielGeriatric Research Education and Clinical Center (GRECC), Veterans' Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Jennifer RidenourGeriatric Research Education and Clinical Center (GRECC), Veterans' Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Alexandria NguyenGeriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Oteshia HicksGeriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Taissa A BejGeriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Nadim G El ChakhtouraGeriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Lillian MinDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrzej GaleckiDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Todd GreeneDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Mary-Claire RoghmannDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Laxmi ChigurupatiJohn D. Dingell Department of Veterans Affairs Medical Center, Detroit, MI, USA.
Federico PerezGeriatric Research Education and Clinical Center (GRECC), VA Northeast Ohio Healthcare System, Cleveland, OH, USA.
Robin L P JumpGeriatric Research Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Biomedical Informatics and Data Science Training Program (BIDS-TP)T32GM141746 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ivo D Dinov, RYAN E MILLS · 2021 to 2026
$2.6M
Genomic methods for studying microbial transmission in healthcare settingsR01AI175227 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Evan Snitkin · 2023 to 2026
$2.1M
Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training ProgramK24AG050685 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody · 2015 to 2026
$1.4M
AHRQ HHS R01 HS025451CSRD VA I01 CX001691HSRD VA IK6 HX003399HSRD VA RCS 11-222NCATS NIH HHS UL1 TR002240NIAID NIH HHS R01 AI175227NIA NIH HHS K24 AG050685NIA NIH HHS P30 AG024824NIGMS NIH HHS T32 GM141746
6 · The paper itself

Abstract

Nursing home (NH) residents in the United States routinely attend interactive visits for services such as therapy or dialysis, creating opportunities for pathogen transmission. A paucity of studies exist which delineate spread of pathogens beyond residents' in-room environment. In this prospective cohort study, we recruited 197 newly-admitted residents across three Veterans Affairs NHs to characterize multidrug-resistant organism (MDRO) prevalence, acquisition, and transmission. Participant hands, nares, groin, and seven environmental surfaces were swabbed during 758 regularly scheduled in-room visits; participant hands, healthcare personnel hands, and equipment were swabbed during 345 unscheduled interactive visits. We demonstrate that baseline MDRO colonization and new acquisition is common, and one in six interactive visits result in MDRO transmission. Whole genome sequencing on a subset of participants enabled us to identify sources of transmission where it was unknown using microbiologic methods alone. Our results illustrate MDRO transmission pathways and highlight the need for innovative, multidisciplinary interventions.

Indexed as

Cross InfectionDrug Resistance, Multiple, BacterialNursing HomesAgedAged, 80 and overAnti-Bacterial AgentsFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesUnited StatesWhole Genome SequencingAnti-Bacterial Agents

Identifiers

PMID40082431
PMCPMC11906779

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.