ArticleNature communications2025
Copper-catalysed dynamic kinetic asymmetric C-O cross-coupling to access chiral aryl oxime ethers and diaryl ethers.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A biocatalytic platform for the stereoselective synthesis of diverse atropisomeric compounds using engineered metalloenzymes.Science advances · 2026Article
- Dynamic palladium catalysis enables chiral amplification toward acyclic Schiff base atropisomers.Nature communications · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Dynamic kinetic resolution (DKR) has emerged as an elegant and powerful tool for enantioselective synthesis, enabling the transformation of racemic compounds into enantiomerically enriched products with theoretically quantitative yields. Despite its widespread success, the dynamic kinetic asymmetric C-O cross-coupling has presented significant challenges and remains unexplored. In this study, we report a dynamic kinetic asymmetric C-O cross-coupling of oximes and phenols via copper/BOX-catalysed enantioselective O-arylation with diaryliodonium salts. This method efficiently produces a wide range of inherently chiral oxime ethers, as well as axially chiral styrenes, with high yields and excellent regio- and enantioselectivities. Through controlled experiments and Density Functional Theory (DFT) studies, we have elucidated the dynamic kinetic resolution process and gained insights into the origins of regio- and enantioselectivity.
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Registered trials
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