Evidence map›Paper›PMID 40082396›Full record

ArticleNature communications2025

HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1.

Zhao-Jun Pan, Wei-Lun Wei, Phuong-Anh Tran, Ru-Ying Fang, Thanh Ha Pham, John L Bowman, Chao-Tzu Chung, Bing-Nan Shen, Ju-Ting Yang, Han-Han Chang and 13 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Zhao-Jun Pan *Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Wei-Lun Wei *Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Phuong-Anh Tran *Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.ORCID http://orcid.org/0009-0009-4786-3819
Ru-Ying FangInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Thanh Ha PhamInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
John L BowmanSchool of Biological Science, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-7347-3691
Chao-Tzu ChungInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Bing-Nan ShenInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Ju-Ting YangInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Han-Han ChangJoint Center for Instruments and Researches, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Wann-Neng JaneInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.
Chiung-Hsiang ChengJoint Center for Instruments and Researches, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Chia-Chi WangJoint Center for Instruments and Researches, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Hsin-Yi WuInstrumentation Center, National Taiwan University, Taipei, Taiwan.
Syuan-Fei HongInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Qian-Wen ShangInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Sin-Fen HuInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Pin-Chun LinInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Fu-Hui WuAgriculture Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
Choun-Sea LinAgriculture Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.
Yu-Ling HungInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan.ORCID http://orcid.org/0009-0006-7804-1373
Tang-Long ShenCenter of Biotechnology, National Taiwan University, Taipei, Taiwan.
Shih-Shun LinInstitute of Biotechnology, National Taiwan University, Taipei, Taiwan. linss01@ntu.edu.tw.ORCID http://orcid.org/0000-0002-7295-5004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 methyltransferase activity. This study investigated the inhibitory potential of HC-Pros from different potyviruses in transgenic plants. P1/HC-Pro from turnip mosaic virus (P1/HC-Pro

Indexed as

ArabidopsisArabidopsis ProteinsArgonaute ProteinsAutophagyCysteine EndopeptidasesMethyltransferasesViral ProteinsGene Expression Regulation, PlantMicroRNAsNicotianaPlants, Genetically ModifiedPotyvirusRNA InterferenceAGO1 protein, ArabidopsisArabidopsis ProteinsArgonaute ProteinsCysteine EndopeptidasesHC-Pro protein, potyvirusHEN1 protein, ArabidopsisMethyltransferasesMicroRNAsViral Proteins

Identifiers

PMID40082396
PMCPMC11906750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.