Evidence map›Paper›PMID 40082364›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Caenorhabditis elegans as a Screening Platform for Anti-aging Compounds.

Eirini Mytilinaiou, Katerina Kitopoulou, Konstantinos Palikaras

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Probiotic Modulation in Aging: Strain-Specific Geroprotective Effects inInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eirini Mytilinaiou *Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Katerina Kitopoulou *Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos PalikarasDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. palikarask@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As global life expectancy continues to rise, the need to understand and mitigate the effects of aging on human physiology has become increasingly important. Aging is characterized by cellular and functional decline, resulting in a higher prevalence of chronic diseases. Model organisms, such as Caenorhabditis elegans, provide valuable insights into the molecular mechanisms underlying aging and serve as platforms for developing potential therapeutic interventions. This chapter highlights the utility of C. elegans in aging research by presenting three straightforward protocols: the lifespan assay, thrashing assay, and lipofuscin accumulation assay. These assays are designed to effectively assess key physiological aspects of organismal health and provide a reliable framework for monitoring the aging process and evaluating anti-aging compounds. Here, we demonstrate the application of these protocols using Urolithin A as an example, underscoring their efficacy in advancing our understanding of aging and contributing to the development of potential interventions.

Indexed as

AgingCaenorhabditis elegansAnimalsDrug Evaluation, PreclinicalHumansLipofuscinLongevityLipofuscinAgingAnti-aging compoundsBody bendingCaenorhabditis elegansLifespanLipofuscinNematodeThrashing

Identifiers

PMID40082364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.