ArticleMethods in molecular biology (Clifton, N.J.)2025
Two-Replication Round, Telomere Strand-Specific, Chromosome Orientation Fluorescent In Situ Hybridization.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Telomere strand-specific, two-replication-round, chromosome orientation fluorescence in situ hybridization (2R telomeric-CO-FISH) is a molecular cytogenetic protocol that allows simultaneous detection of genomic and telomeric sister chromatid exchanges along with telomeric intrachromosomal conservative break-induced replication. The combination of differential sister-chromatid and strand-specific telomeric labeling, provides information about intrachromosomal DNA recombinational events occurring in the last two consequent replication rounds of living cells grown in the presence of nucleic acid analogs. Despite a plethora of research applications, this methodology can be used to validate the extent of exposure to genotoxic agents and efficiency of recombinational DNA repair.
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