Trial reportSkeletal radiology2025
The association between articular calcium crystal deposition and knee osteoarthritis, joint pain and inflammation: a cross-sectional study.
Trial report in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Management of Musculoskeletal Injuries with an Inflammatory Damage-Associated Molecular Pattern (DAMP) Etiology.Pain and therapy · 2026Review
- The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study.Osteoarthritis and cartilage · 2026Observational
- The 18th international workshop on osteoarthritis imaging. Structure and pain: Where are we today?Osteoarthritis imaging · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore in a cross-sectional fashion if overweight individuals with knee osteoarthritis (OA) and intraarticular calcium crystal (CaC) deposits experience more knee joint inflammation and knee pain compared with individuals without CaC deposits. SUBJECTS AND
methodsWe used pre-randomization imaging data from an RCT, the LOSE-IT trial. Participants with knee OA (clinical diagnosis of knee OA and KLG 1-3) had CT and 3 T MRI of the index knee. CaCs were assessed on CT using the Boston University Calcium Knee Score (BUCKS). The pain subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to assess knee pain and to estimate joint inflammation we used static and dynamic contrast-enhanced (DCE) MRI. An independent sample t-test was used to test for a significant difference in KOOS-pain and Analysis of Covariance (ANCOVA) models to test for differences in the static and DCE-MRI variables between the two groups.
resultsOf the 158 participants with KOOS-pain available, 19 (12%) had CaC deposits, and of the 115 participants with MRI available, 13 (11.3%) had CaC deposits. We did not find a significant difference in mean KOOS-pain between the two groups; the mean difference was - 2.2 points (95%CI, - 10.86, 6.45). None of the MRI variables were associated with the presence of CaC deposits. Between-group differences were small for all MRI variables, with standardized mean differences ranging from small to medium (0.31-0.56).
conclusionIn individuals with knee OA, we did not find an association between intraarticular CaC deposits and an increase in knee joint inflammation or knee pain.
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