SynthesisPituitary2025
Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature.
Synthesis in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Beyond biochemical control: factors associated with quality of life in patients with acromegaly.Pituitary · 2026Article
- Assessment of nurses' knowledge and awareness of acromegaly in a high-volume tertiary center: a cross-sectional study.Pituitary · 2026Article
- Symptom severity and exacerbation frequency in medically treated patients with acromegaly.Pituitary · 2026Article
- Bone and joint quality remains impaired in long-term controlled acromegaly: an HR-pQCT study.Journal of the Endocrine Society · 2026Article
- Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026Review
- The acromegaly patient experience: burden of treatment and quality of life.The Journal of clinical endocrinology and metabolism · 2026Review
- Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.Pituitary · 2026Review
- Article
- Importance of the early diagnosis of acromegaly. Evolution of mandibular growth and dental occlusion in a case with a late diagnosis.Journal of clinical and experimental dentistry · 2025Review
- Static and Dynamic Balance Is Impaired in Patients With Long-Term, Well-Controlled Acromegaly: A Cross-Sectional Study.Clinical endocrinology · 2025Article
- Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to evaluate the risk of psychiatric disorders through a retrospective cohort study comparing acromegaly and non-functioning pituitary adenomas (NFPAs) and a meta-analysis of existing literature.
methodsThe cohort study included data from patient records analyzed using Chi
resultsThe study population comprised 105 acromegaly and 211 NFPA patients, with similar sex distributions. Patients with acromegaly presented with smaller pituitary adenomas (17.9 (SD: 9.9) mm vs. 22.9 (SD: 10.6) mm, p < 0.001), more frequent pituitary surgery (89.1 vs. 60.2%, p < 0.001) and hormone replacement therapy (25.7 vs. 16.1%, p = 0.042). Acromegaly patients had higher risk of depression (RR: 1.9, CI95% [1.2-3.2], p = 0.009), and increased need of admissions to the psychiatric ward (5.7 vs. 0.5%, p = 0.006). The relative risk of anxiety was 1.4 (CI95% [0.5-4.4], p = 0.53). Daily opioid use was higher in acromegaly patients with psychiatric morbidity which was associated with a diagnosis of arthropathy (p = 0.009). From the meta-analysis (8 studies, 1387 patients) an increased risk of depression (RR:1.8, CI95% [1.3-2.5]) and anxiety (RR:1.9, CI95% [1.1-3.2]) was observed in acromegaly compared to NFPAs.
conclusionThis study reveals a higher risk of psychiatric disorders in acromegaly, particularly depression and anxiety. Consequently, a need for increased psychiatric awareness in acromegaly is warranted.
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