ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025
Dog allergen-induced asthma in mice: a relevant model of T2
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Neutrophilic asthma: advances in experimental models from pathogenesis to therapeutic translation.Molecular medicine (Cambridge, Mass.) · 2026Review
- SARS-CoV-2 causes gastric damage: structural and ultrastructural evaluation.Journal of molecular histology · 2025Article
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Authors and funding
11 authors.
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Abstract
OBJECTIVE AND
designAirway remodelling (AR) is a disabling phenomenon in patients with severe asthma, yet suitable models are lacking. We previously developed a dog allergen-induced murine asthma model characterized by T2 MATERIAL: Asthma was induced in C57BL/6 J mice by intranasal sensitization, followed by a three-week challenge with dog allergen. TREATMENT: Daily intraperitoneal 1 mg kg
methodsWe measured airway resistances in response to methacholine, cellular inflammation in bronchoalveolar lavage, lung cytokines, and quantified AR features, in response to dexamethasone.
resultsDexamethasone-treated mice showed persistent airway hyperresponsiveness, neutrophilic inflammation, and Il17a overexpression, whereas Il22 expression was abrogated. Pathological AR features, including mucus hyperproduction, subepithelial fibrosis and smooth muscle hypertrophy were not eliminated by dexamethasone.
conclusionsOur dog allergen-induced murine model of asthma mirrors the steroid-insensitive traits of human severe T2
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