Evidence map›Paper›PMID 40082264›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Myocardial blood flow reference values for 13N-ammonia PET myocardial perfusion imaging in patients without flow-limiting coronary artery disease.

Rita Pingree, Susanne Markendorf, Dimitrios Moysidis, Christoph Ryffel, Magdalena Stuetz, Raffael Ghenzi, Marko Gajic, Dominik C Benz, Aju P Pazhenkottil, Andreas A Giannopoulos and 3 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Diagnosis of multivessel coronary artery disease usingJapanese journal of radiology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rita Pingree *Department of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Susanne Markendorf *Department of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Dimitrios MoysidisDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Christoph RyffelDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Magdalena StuetzDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Raffael GhenziDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Marko GajicDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Dominik C BenzDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Andreas A GiannopoulosDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
Simon WintherDepartment of Cardiology, Gødstrup Hospital, Herning, Denmark.
Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland. ronny.buechel@usz.ch.ORCID 0000-0001-8064-8904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the most important patient factors influencing quantitative MBF and to report the lower (LRL) and upper (URL) reference limits for 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI).

methodsPatients who underwent 13N-ammonia PET-MPI were screened, and those with evidence of myocardial ischemia or scar, known cardiomyopathy, impaired left ventricular function, non-response to vasodilators, and those who underwent a stress-rest protocol were excluded. Multiple linear regression analyses were performed to identify independent predictors of rest MBF (rMBF), stress MBF (sMBF), and myocardial flow reserve (MFR), and predictor importance was calculated. Finally, median, LRL, and URL for rMBF, sMBF, and MFR were calculated based on the presence of predictors.

resultsAmong 784 patients with a median coronary artery calcium score (CACS) of 69, median rMBF was 0.75mL∙min

conclusionIn patients without flow-limiting CAD, MBF is strongly influenced by the patient's habitus, whereby median and reference limits for sMBF and rMBF decrease with increasing BMI. Consequently, MFR exhibits stable lower reference limits across a wide range of BMI and may be considered the most robust quantitative parameter derived from 13N-ammonia PET-MPI.

Indexed as

AmmoniaCoronary Artery DiseaseCoronary CirculationMyocardial Perfusion ImagingNitrogen RadioisotopesPositron-Emission TomographyAgedFemaleHumansMaleMiddle AgedReference ValuesAmmoniaNitrogen-13Nitrogen RadioisotopesMyocardial blood flowMyocardial flow reserveNormal valuesPositron emission tomographyReference values

Identifiers

PMID40082264
PMCPMC12222243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.