Evidence map›Paper›PMID 40082203›Full record

ArticleJournal of Zhejiang University. Science. B2025

OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia.

Ziyin Yang, Lei Hai, Xiaoyu Chen, Siwen Wu, Yan Lv, Dawei Cui, Jue Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ziyin YangDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Lei HaiDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Xiaoyu ChenDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Siwen WuDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Yan LvDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Dawei CuiDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. daweicui@zju.edu.cn.
Jue XieDepartment of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. zyyyxj2011@zju.edu.cn.

Funding

the National Natural Science Foundation of China 82172335, 81971994, 91846103 and 81871709the Zhejiang Provincial Key Research and Development Program 2020C03032
6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury. ITP has complicated immunopathological mechanisms that need further elucidation. It is well known that the costimulatory molecules OX40 ligand (OX40L) and OX40 play essential roles in the immunological mechanisms of autoimmune diseases. Previously, we discovered that the expression of

Indexed as

OX40 LigandPurpura, Thrombocytopenic, IdiopathicT Follicular Helper CellsT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationFemaleHumansMiceMice, Inbred C57BLReceptors, OX40Signal TransductionOX40 LigandReceptors, OX40Tnfsf4 protein, mouseB cellFollicular helper T (Tfh) cellImmune thrombocytopeniaOX40OX40 ligand (OX40L)

Identifiers

PMID40082203
PMCPMC11906389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.