Evidence map›Paper›PMID 40082178›Full record

ReviewThe journal of prevention of Alzheimer's disease2025

Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review.

Claudie Hooper, Nicola Coley, Julien Delrieu, Sophie Guyonnet

Registry-linked trialAbstract readReview
In one paragraph

Review in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07731191 (Development of Digital Solutions for the Prediction of the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07731191 narecruitingnot on this mapstarted 2026, after this paper: background citation

Development of Digital Solutions for the Prediction of the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors (PrevAI)

TypeinterventionalSponsorIRCCS Centro San Giovanni di Dio FatebenefratelliRan2026 to 2026Enrolled240ConditionsMild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)ArmsDigital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Purpose in life and blood-based biomarkers of brain health.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  4. Article
  5. Observational
  6. Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Preventing Alzheimer's disease by correcting lifestyle factors?The journal of prevention of Alzheimer's disease · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claudie HooperIHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France. Electronic address: braines.c@chu-toulouse.fr.
Nicola ColeyAging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), INSERM-University of Toulouse, 37 allées Jules Guesde, 31073 Toulouse, Toulouse, France; Department of Epidemiology and Public Health, Toulouse University Hospital, 37 allées Jules Guesde, 31073 Toulouse, Toulouse, France; IHU HealthAge, Cité de la santé, place Lange, 31059 Toulouse, France. Electronic address: nicola.coley@inserm.fr.
Julien DelrieuIHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France; CERPOP Inserm UMR 1295, Toulouse, France. University of Toulouse, Toulouse, France. Electronic address: delrieu.j@chu-toulouse.fr.
Sophie GuyonnetIHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France; CERPOP Inserm UMR 1295, Toulouse, France. University of Toulouse, Toulouse, France. Electronic address: guyonnet.s@chu-toulouse.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as a minimally invasive tool for disease detection and monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, and social isolation) and plasma biomarkers of AD: Aβ

Indexed as

Alzheimer DiseaseBiomarkersLife StyleAmyloid beta-PeptidesExerciseHumanstau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer's diseaseBiomarkersINSPIRELifestylePlasma

Identifiers

PMID40082178
PMCPMC12434245

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.