Evidence map›Paper›PMID 40082066›Full record

ArticleInternational journal of stem cells2025

Effects of Dexamethasone and Tacrolimus on Mesenchymal Stem Cell Characteristics and Gene Expression.

Na Kyung Lee, Duk L Na, Su Hyeon Myeong, Seung-Yeon Lee, Na-Hee Lee, Hyemin Jang, Sang Won Seo, Jong Wook Chang, Hee Jin Kim, Hyo Jin Son

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na Kyung LeeDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0000-0001-6116-2562
Duk L NaAlzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-0098-7592
Su Hyeon MyeongDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0009-0009-6843-3332
Seung-Yeon LeeDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0009-0008-2462-0032
Na-Hee LeeDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0009-0000-9486-0391
Hyemin JangDepartment of Neurology, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-3152-1274
Sang Won SeoCell and Gene Therapy Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8747-0122
Jong Wook ChangDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea.ORCID https://orcid.org/0000-0001-9335-5510
Hee Jin KimCell and Gene Therapy Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-3186-9441
Hyo Jin SonCell and Gene Therapy Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-9264-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are frequently used for therapeutic applications in both pre-clinical and clinical settings owing to their capacity for immune modulation and neuroprotective effects. However, transient fever is commonly observed as an adverse event following MSC injection in patients with Alzheimer's disease (AD). In this study, we investigated the potential impact of immunosuppressants such as dexamethasone and tacrolimus on altering the characteristics of human mesenchymal stem cells (hMSCs). Additionally, we examined whether these immunosuppressants affect the persistence of hMSCs or the immune response upon their administration into the brain parenchyma of AD mice. The exposure of hMSCs to high concentrations of dexamethasone and tacrolimus

Indexed as

Alzheimer's diseaseFeverImmunityImmunosuppressive agentsMesenchymal stem cells

Identifiers

PMID40082066
PMCPMC12122247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.