Evidence map›Paper›PMID 40082065›Full record

ArticleInternational journal of stem cells2025

Extracellular Vesicles from Induced Mesenchymal Stem Cells Inhibit Acute Kidney Injury to Chronic Kidney Disease Transition.

Hongduk Kim, Sungok Hong, Soo Kim, Tae Min Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hongduk KimInstitutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Korea.ORCID https://orcid.org/0009-0002-0311-3038
Sungok HongGraduate School of International Agricultural Technology, Seoul National University, Pyeongchang, Korea.ORCID https://orcid.org/0009-0009-2707-4265
Soo KimBrexogen Research Center, Brexogen Inc., Seoul, Korea.ORCID https://orcid.org/0000-0002-1818-0551
Tae Min KimInstitutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Korea.ORCID https://orcid.org/0000-0003-0015-2701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with conventional mesenchymal stem cells (MSCs), induced mesenchymal stem cells (iMSCs) from induced pluripotent stem cells are unique cell sources for tissue regeneration. The effect of extracellular vesicles (EVs) secreted from iMSCs on inhibiting acute kidney injury (AKI) to chronic kidney disease (CKD) transition was not reported. In this study, we investigated whether EVs from iMSCs (iMSC-EVs) could inhibit AKI-to-CKD transition. iMSC-EVs exhibited the general characteristics of EVs, such as protein marker expression, morphology, and size. Additionally, iMSC-EVs were detected in renal tissues after intravenous injection. In human renal tubular epithelial cells, the increase in pro-fibrotic gene expression in response to transforming growth factor

Indexed as

Acute kidney injuryChronic kidney diseaseExtracellular vesiclesInduced mesenchymal stem cell

Identifiers

PMID40082065
PMCPMC12394081

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.