Evidence map›Paper›PMID 40082008›Full record

ArticleBMJ open2025

Hand function impairment in Systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) - a longitudinal observational multicentre study protocol.

Mark Greveling, Voon H Ong, Christopher Denton, Wouter Foppen, Amin Herman, Nick Jeffries-Owen, Marion Kortekaas, Ilse Masselink, Douwe J Mulder, Rita Schriemer and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06133244 (Hand Function Impairment in Systemic Sclerosis), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06133244 recruitingnot on this map

Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) Study

TypeobservationalSponsorUMC UtrechtRan2024 to 2028Enrolled300ConditionsSystemic SclerosisArmsImaging, blood samples, fuctional tests and physical examination
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mark GrevelingDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands m.j.greveling@umcutrecht.nl.ORCID http://orcid.org/0000-0003-3811-6511
Voon H OngDepartment of Medicine, Department of Inflammation, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, UK.
Christopher DentonDepartment of Medicine, Department of Inflammation, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, UK.
Wouter FoppenDepartment of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-4970-8555
Amin HermanDepartment of Rheumatology, St Antonius Hospital, Nieuwegein, The Netherlands.
Nick Jeffries-OwenSRUK, London, UK.
Marion KortekaasDepartment of Rheumatology, Leids Universitair Medisch Centrum, Leiden, The Netherlands.
Ilse MasselinkDepartment of Revalidation, UMC Utrecht, Utrecht, The Netherlands.
Douwe J MulderDepartment of Internal Medicine, Division of Vascular Medicine, UMCG, Groningen, The Netherlands.
Rita SchriemerDutch Patient Organization for Systemic Autoimmune Diseases, NVLE, Utrecht, The Netherlands.
Madelon C VonkDepartment of Rheumatology, Radboudumc, Nijmegen, The Netherlands.
Jeska K de Vries-BouwstraDepartment of Rheumatology, Leids Universitair Medisch Centrum, Leiden, The Netherlands.
Paco WelsingDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.
Simon MastbergenDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.
Julia SpieringsDepartment of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-2546-312X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe majority of all patients with systemic sclerosis (SSc) experience hand function impairment. The exact cause for this impairment is yet unknown. As impaired hand function hugely impacts daily functioning and quality of life, there is a high unmet need for effective treatments. With the availability of new imaging modalities, biomarkers and laboratory techniques, opportunities arise to increase insights into the factors contributing to hand function impairment. The objective of this study is to identify risk factors and underlying mechanisms leading to hand function impairment in SSc. METHODS AND ANALYSIS: This is a longitudinal observational multicentre study in patients with very early diagnosis of systemic sclerosis and SSc under care of the Department of Rheumatology and Clinical Immunology of the University Medical Centre Utrecht (UMCU), St Antonius Hospital Nieuwegein, UMC Groningen (UMCG), Leiden UMC (LUMC), Radboudumc or Royal Free Hospital (RFH) London. Patients will be followed for 2 years. Medical history, clinical status, nailfold capillaroscopy, skin assessments, serum biomarker analysis, ultrasound, elastography and MRI will be performed, and results related to hand function measurements will be analysed. ETHICS AND DISSEMINATION: This study was approved by the Medical Research Ethics Committee NedMec (MREC NedMec) in the Netherlands and by HRA and Health and Care Research Wales in the UK. Results will be published in scientific journals and presented at scientific congresses and patient meetings. TRIAL REGISTRATION NUMBER: NCT06133244. PROTOCOL VERSION: V1.3 6-06-2024.

Indexed as

HandScleroderma, SystemicAdultBiomarkersFemaleHumansLongitudinal StudiesMaleMulticenter Studies as TopicObservational Studies as TopicQuality of LifeResearch DesignBiomarkersObservational StudyRHEUMATOLOGYUltrasound

Identifiers

PMID40082008
PMCPMC11907010

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.