ReviewAnnual review of chemical and biomolecular engineering2025
Engineering Protein-Polyelectrolyte Interactions for Cellular Applications.
Review in Annual review of chemical and biomolecular engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Complexation of Polypeptides and Polypeptoids with Nucleic Acids: Does Chirality Matter for Salt Stability and Morphology?Biomolecules · 2026Article
- Macromolecular dimensions of a synthetic polyelectrolyte as a factor in its interactions with protein and cells: desirability for longer chains.Journal of materials chemistry. B · 2026Article
- Electrostatic Self-Assembly of Protein Nanoparticles from Intrinsically Disordered Polypeptide and Globular Protein Pairs.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Protein-polyelectrolyte interactions are fundamental interactions in biology that occur at every length scale, from protein-DNA complexes to phase-separated organelles. They drive processes ranging from gene transcription and DNA synthesis to viral assembly. Protein engineering is a powerful way to modulate these interactions, both to probe endogenous function and to engineer novel interactions between species. In this review, we consider the various noncovalent interactions that govern the formation and behavior of these complexes, and we discuss how protein modifications such as changes to structure, charge, and charge patterning affect them. We highlight recent examples where engineering changes to protein-polyelectrolyte interactions have helped elucidate biological function, and we then focus on recent efforts toward de novo material design of synthetic biomolecular condensates and functional nanoassemblies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.