Evidence map›Paper›PMID 40081958›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen-Targeted

Kjetil Berner, Eivor Hernes, Monika Kvassheim, Mona-Elisabeth Revheim, Julie Bastiansen, Silje Selboe, Charlotte L Bakken, Simen R Grønningsæter, Øyvind S Bruland, Roy H Larsen and 3 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Chemical & biomedical imaging · 2026
    Article
  2. Review
  3. Picolinamide-functionalized macrocyclic chelators forInorganic chemistry frontiers · 2026
    Article
  4. First-in-human evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Refining the clinical utility of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Review
  9. Therapeutic evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Combination of PSMA targeting alpha-emitting radioligand [Medical oncology (Northwood, London, England) · 2025
    Article
  11. EJNMMI radiopharmacy and chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kjetil BernerDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Eivor HernesDepartment of Nuclear Medicine, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Monika KvassheimDepartment of Physics and Computational Radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Mona-Elisabeth RevheimDepartment of Nuclear Medicine, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Julie BastiansenDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Silje SelboeDepartment of Nuclear Medicine, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Charlotte L BakkenDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Simen R GrønningsæterDepartment of Physics and Computational Radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Øyvind S BrulandDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Roy H LarsenSciencons AS, Oslo, Norway; and.
Lily BouzelmatARTBIO Limited, London, United Kingdom.
Vicki L JardineARTBIO Limited, London, United Kingdom.
Caroline StokkeDepartment of Physics and Computational Radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; carsto@ous-hf.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AB001, a prostate-specific membrane antigen (PSMA)-targeted small molecule labeled with the in vivo-generating α-emitter

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IILead RadioisotopesProstatic Neoplasms, Castration-ResistantAgedHumansLigandsMaleMiddle AgedNeoplasm MetastasisRadiopharmaceuticalsSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILead-212Lead RadioisotopesLigandsRadiopharmaceuticals212PbimagingmCRPCPSMAtargeted α-therapyα-radioligand therapy

Identifiers

PMID40081958
PMCPMC12051763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.