Evidence map›Paper›PMID 40081937›Full record

ArticleHeart (British Cardiac Society)2025

Cardiovascular disease burden and risk factor management in cancer survivors: insights into a multiethnic, socioeconomically deprived urban population.

Liliana Szabo, Jackie Cooper, Dorina-Gabriela Condurache, Isabel Dostal, Gracia Andriamiadana, Rohini Mathur, Fiona M Walter, Mamas A Mamas, Charlotte H Manisty, Nicholas C Harvey and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liliana SzaboWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Jackie CooperWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Dorina-Gabriela ConduracheWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.ORCID 0000-0003-3985-0814
Isabel DostalWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Gracia AndriamiadanaWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Rohini MathurWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Fiona M WalterWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Mamas A MamasKeele Cardiovascular Research Group, Keele University, Newcastle-under-Lyme, UK.ORCID 0000-0001-9241-8890
Charlotte H ManistyBarts Heart Centre, Saint Bartholomew's Hospital Barts Heart Centre, London, UK.ORCID 0000-0003-0245-7090
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Steffen E PetersenWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.ORCID 0000-0003-4622-5160
John RobsonWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Zahra Raisi-EstabraghWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK z.r.raisi-estabragh@qmul.ac.uk.ORCID 0000-0002-7757-5465

Funding

British Heart Foundation (FS/17/81/33318)Medical Research Council MC_PC_21003; MC_PC_21001Wellcome TrustWellcome Trust (218584/Z/19/Z)
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) burden and risk factor management among cancer survivors, especially in socioeconomically deprived, multiethnic populations, remain understudied. This study examines CVD burden and risk factor control in survivors of 20 cancer types within a diverse urban population.

methodsThis matched cohort study used electronic health records from 127 urban primary care practices. Cancer survivors were matched to non-cancer comparators at a 1:4 ratio. Cancer and CVD diagnoses were defined using standard clinical code sets. Sociodemographic variables, lifestyle behaviours, blood pressure, cholesterol levels and statin prescriptions were analysed. Multivariable regression evaluated associations between cancer history, CVD prevalence and risk factor control.

resultsThe cohort included 18 839 cancer survivors (43% men, average age 64±15 years), with high ethnic diversity (48% White, 24% Black, 22% Asian) and high deprivation levels. Cancer survivors had elevated odds of all CVDs considered, independent of shared risk factors. Heart failure was more common in haematological (OR 2.12; 95% CI 1.44 to 3.09) and breast cancer survivors (OR 1.38; 95% CI 1.16 to 1.64). Patients with bladder (OR 1.50; 95% CI 1.20 to 1.87) and lung cancer (OR 1.44; 95% CI 1.09 to 1.87) had higher odds of ischaemic heart disease. Venous thromboembolism risk was highest in ovarian cancer (OR 5.72; 95% CI 3.54 to 9.32). Blood pressure control was slightly better in cancer survivors (OR 0.92; 95% CI 0.87 to 0.97), yet one in three patients did not meet guideline-directed targets. Statin use and cholesterol management were similar between survivors and controls, but disparities were observed within certain ethnic groups.

conclusionCancer survivors have an elevated risk of CVD, with variations by cancer type and ethnicity. Despite comparable or slightly better control of major risk factors, a significant proportion of cancer survivors do not achieve guideline-recommended targets, highlighting the need for optimised management strategies, particularly in high-risk subgroups.

Indexed as

Cancer SurvivorsCardiovascular DiseasesNeoplasmsUrban PopulationAgedCost of IllnessFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedPrevalenceRisk AssessmentRisk FactorsSocioeconomic FactorsCardiovascular DiseasesCohort StudiesEpidemiologyOutcome Assessment, Health CareRisk Factors

Identifiers

PMID40081937
PMCPMC12703254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.