ArticlePlant biotechnology journal2025
MsbZIP55 regulates salinity tolerance by modulating melatonin biosynthesis in alfalfa.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Time-Course Transcriptomic Analysis IdentifiesPlants (Basel, Switzerland) · 2026Article
- Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Overexpression of SerotoninAntioxidants (Basel, Switzerland) · 2026Article
- Tomato NAC2-DREB2 module fine-tunes saline-alkali stress sensitivity via modulation of melatonin biosynthesis and ROS homeostasis.Horticulture research · 2026Article
- Exogenous melatonin increases alfalfa (Medicago sativa L.) tolerance to salt stress.BMC plant biology · 2026Article
- MsWRKY49 Modulates Pollen Tube Elongation in Response to Boron Deficiency by Regulating Reactive Oxygen Species Homeostasis in Alfalfa.Plant biotechnology journal · 2026Article
- Microbial exopolysaccharide pullulan-based seed priming combined with Chlorella vulgaris enhances salinity tolerance in maize.World journal of microbiology & biotechnology · 2026Article
- The regulatory roles of flavonoids, melatonin, and glycine betaine in plant salt stress response.Frontiers in plant science · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
Soil salinity is a severe abiotic stress that damages plant growth and development. As an antioxidant and free radical scavenger, melatonin is well known for helping plants survive abiotic conditions, including salinity stress. Here, we report that the salt-related gene MsSNAT1, encoding a rate-limiting melatonin biosynthesis enzyme, is located in the chloroplast and contributes to salinity stress tolerance in alfalfa. We found that the MsSNAT1 overexpressing alfalfa lines exhibited higher endogenous melatonin levels and increased tolerance to salt stress by promoting antioxidant systems and improving ion homeostasis. Furthermore, through a combination of transcriptome sequencing, dual-luciferase assays and transgenic analysis, we identified that the basic leucine zipper (bZIP) transcription factor, MsbZIP55, is associated with salt response and MsSNAT1 expression. EMSA analysis and ChIP-qPCR uncovered that MsbZIP55 can recognize and directly bind to the MsSNAT1 promoter in vitro and in vivo. MsbZIP55 acts as a negative regulator of MsSNAT1 expression, thereby reducing melatonin biosynthesis. Morphological analysis revealed that overexpressing MsbZIP55 conferred salt sensitivity to transgenic alfalfa through a higher Na
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Registered trials
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