ArticleAnnals of hepatology
Racial differences in primary sclerosing cholangitis: A retrospective cohort study leveraging a new ICD-10 code.
Article in Annals of hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Symptom burden is associated with health-related quality of life in symptomatic adults with primary sclerosing cholangitis.Hepatology communications · 2026Article
- Identification of Primary Sclerosing Cholangitis: ICD-10 Code Validation and Comparison with a Large Language Model Approach.Digestive diseases and sciences · 2026Article
- Design and evaluation of PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Identification of primary sclerosing cholangitis: ICD-10 code validation and comparison with a large language model approach.Research square · 2026Article
- The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease.Hepatology communications · 2026Review
- Racial Disparities in Comorbidity Patterns of Early-Onset Liver Cancer: A Machine Learning Analysis.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
6 authors.
Funding
Abstract
INTRODUCTION AND
objectivesThere are limited data examining racial disparities in PSC-related clinical features and events. We aimed to leverage a new PSC ICD-10 code to characterize racial differences in a nationwide contemporary cohort of patients with PSC. PATIENTS AND
methodsWe used de-identified clinical/administrative data from the Vizient® Clinical Data Base to identify outpatient and inpatient adult patients with PSC using a PSC-specific ICD-10-CM code (K83.01). We compared demographic and clinical characteristics between patients who self-identified as Black versus White race. Primary and secondary outcomes included clinical and healthcare utilization outcomes.
resultsWe identified 9850 patients with PSC: 79% White, 13% Black, 2% Asian, and 6% other. Compared with White patients, Black PSC patients were more likely to be female, younger, and have a higher Elixhauser Comorbidity Index (p<0.001). Black patients were less likely to have concurrent inflammatory bowel disease (IBD) but more likely to have overlap syndromes (p<0.001) compared to White patients. The black race was significantly associated with intensive care unit stays (aOR 1.69, 95%CI 1.38-2.06) and longer length of stay (aIRR 1.15, 95%CI 1.04-1.28), but similar total number of hospitalizations (aIRR 1.05, 95%CI 0.98-1.13) compared to the White race.
conclusionsBlack patients had sociodemographic and clinical features suggestive of more severe disease compared to White patients. Although hospitalization rates were similar, Black patients received higher-intensity care. There was no significant difference in liver transplantation between Black and White patients. Additional research on optimal diagnosis and management of PSC in Black populations specifically is necessary to reduce healthcare disparities in this disease.
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