ArticleThe journal of nutrition, health & aging2025
Association between sarcopenia index and the risk of second hip fracture in older adults.
Article in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Secondary fracture risk after hip fracture in older patients: an updated sex-specific systematic review and meta analysis with GRADE and PAF assessment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Association of the sarcopenia index based on the serum creatinine to cystatin C ratio and genetic risk with venous thromboembolism: a population-based cohort study.Research and practice in thrombosis and haemostasis · 2026Article
- Muscle point-of-care ultrasound as a predictor of mortality in older adults with hip fracture.European geriatric medicine · 2026Observational
- Letter to the editor concerning 'Association between sarcopenia index and the risk of second hip fracture in older adults'.The journal of nutrition, health & aging · 2025Article
- Response to the Letter to the Editor concerning "Association between sarcopenia index and the risk of second hip fracture in older adults" by Liu et al.The journal of nutrition, health & aging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe sarcopenia index (SI), calculated as the ratio of serum creatinine to cystatin C level, represents skeletal muscle mass and strength. This study aimed to investigate the association between SI and the risk of second hip fractures, considering various demographic and clinical factors to improve second hip fracture risk prediction.
methodsThis prospective cohort study included older adults with low-energy hip fractures who were monitored for at least two years to track the incidence of subsequent hip fractures. Baseline demographic, clinical, and biochemical data were collected. The SI was calculated as serum creatinine [mg/dL]/cystatin C [mg/L]) × 100. Logistic regression models were used to evaluate the relationship between the SI and the risk of a second hip fracture. Subgroup analyses were conducted to assess the effects of potential modifiers, including gender, body mass index, hypertension, diabetes, and estimated glomerular filtration rate. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the predictive performance of SI.
resultsA total of 637 patients were included, 59 of whom experienced a second hip fracture during the follow-up period. The patients with second hip fracture exhibited significantly lower SI levels than those without (48.93 ± 8.54 versus 62.95 ± 14.39, P < 0.001). Logistic regression analysis revealed a significant association between a lower muscle-reduction index and an increased risk of a second hip fracture in the fully adjusted model (odds ratio: 0.91; 95% confidence interval: 0.87-0.94; P < 0.001). The area under the ROC curve for predicting a second hip fracture based on the SI was 0.822, indicating good predictive accuracy. Furthermore, subgroup analyses revealed that SI was inversely associated with second hip fracture.
conclusionsThe SI serves as a significant predictor of second hip fractures in older adults, even after considering age, gender, and clinical factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.