Evidence map›Paper›PMID 40080796›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Positioning Imatinib for Pulmonary Arterial Hypertension: A Dose-Finding Phase 2 Study.

Alexander M K Rothman, Sofia S Villar, Jennifer Middleton, Andreas A Roussakis, Frances Varian, Hamza Zafar, Martin Law, Jane Apperley, Imke H Bartelink, Medhat M Said and 6 more

Abstract readAdaptive Clinical TrialClinical Trial, Phase II
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Reply to DingAmerican journal of respiratory and critical care medicine · 2025
    Article
  11. Imatinib: A Promising Therapeutic Shining Light on Pulmonary Arterial Hypertension Treatment.American journal of respiratory and critical care medicine · 2025
    Article
  12. Another Act in the Story of Oral Imatinib for Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Alexander M K RothmanSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0002-7847-4500
Sofia S VillarMRC Biostatistics Unit and.ORCID 0000-0001-7755-2637
Jennifer MiddletonSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0003-4544-8194
Andreas A RoussakisNational Heart and Lung Institute and.ORCID 0000-0001-5748-6978
Frances VarianSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0002-4644-8391
Hamza ZafarSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0003-4651-9636
Martin LawMRC Biostatistics Unit and.
Jane ApperleyCentre for Haematology, Imperial College London, London, United Kingdom.ORCID 0000-0002-1710-1794
Imke H BartelinkDepartment of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID 0000-0001-9602-3407
Medhat M SaidDepartment of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID 0000-0001-7954-6580
Juan A Delgado-SanMartinNational Heart and Lung Institute and.ORCID 0000-0001-7247-0667
David G KielySheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0003-0184-6502
Luke HowardNational Heart and Lung Institute and.ORCID 0000-0003-2822-210X
Mark ToshnerVPD Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3969-6143
S John WortNational Heart and Lung Institute and.ORCID 0000-0003-4287-1173
Martin R WilkinsNational Heart and Lung Institute and.ORCID 0000-0003-3926-1171

Funding

Medical Research Council - National Institute for Health and Care Research Efficacy and Mechanism Evaluation Programme NIHR128465
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypertension, PulmonaryImatinib MesylateAdministration, OralAdultAgedDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedPulmonary Arterial HypertensionTreatment OutcomeVascular ResistanceImatinib Mesylateadaptive trial designimplanted hemodynamic sensorsremote monitoring

Identifiers

PMID40080796
PMCPMC12175952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.