Evidence map›Paper›PMID 40080768›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Efficacy and Safety of Higher Doses of Levofloxacin for Multidrug-resistant Tuberculosis: A Randomized, Placebo-controlled Phase II Clinical Trial.

Patrick P J Phillips, Charles A Peloquin, Timothy R Sterling, Pawandeep Kaur, Andreas H Diacon, Eduardo Gotuzzo, Debra Benator, Robin M Warren, David Sikes, Leonid Lecca and 6 more

Abstract readClinical Trial, Phase IIRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Reply to LiaoAmerican journal of respiratory and critical care medicine · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Patrick P J PhillipsUCSF Center for Tuberculosis and.ORCID 0000-0002-6336-7024
Charles A PeloquinCollege of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, Florida.
Timothy R SterlingDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-4822-6979
Pawandeep KaurDepartment of Global Health, Boston University School of Public Health, Boston, Massachusetts.
Andreas H DiaconTASK, Cape Town, South Africa.ORCID 0000-0001-8641-6792
Eduardo GotuzzoInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID 0000-0003-1747-4352
Debra BenatorInfectious Diseases Section, Washington DC Veterans Affairs Medical Center, George Washington University, Washington, District of Columbia.ORCID 0000-0003-0866-4453
Robin M WarrenDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Science, SAMRC Centre for Tuberculosis, Stellenbosch University, Cape Town, South Africa.
David SikesLaboratory Branch, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia.
Leonid LeccaSocios En Salud Sucursal Perú, Lima, Peru.
Neel R GandhiDepartments of Epidemiology, Global Health, and Medicine and Emory/Georgia Tuberculosis Research Advancement Center, Emory University, Atlanta, Georgia.ORCID 0000-0002-1665-299X
Elizabeth M StreicherDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Science, SAMRC Centre for Tuberculosis, Stellenbosch University, Cape Town, South Africa.
Nancy DianisWestat, Bethesda, Maryland.
Kathleen EisenachTB or NOT TB Consulting, LLC, Little Rock, Arkansas.ORCID 0000-0002-5426-0970
Carole D MitnickDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts; and.
C Robert HorsburghDepartments of Epidemiology, Biostatistics, Global Health, and Medicine, Boston University Schools of Public Health and Medicine, Boston, Massachusetts.ORCID 0000-0001-6838-7895

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Neel Rajnikant Gandhi, Jyothi Rengarajan · 2022 to 2026
$5.8M
Phase 2 Pharmacodynamic Study of High-dose Levofloxacin in MDR-TB TreatmentU01AI100805 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HORSBURGH, CHARLES ROBERT · 2013 to 2016
$5.4M
The impact of alcohol consumption on TB treatment outcomesR01AI119037 · NIAID · BOSTON MEDICAL CENTER · PI JACOBSON, KAREN R · 2016 to 2020
$3.3M
Impact of Pregnancy on TuberculosisR01AI124217 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ELLNER, JERROLD J. · 2015 to 2018
$2.6M
Supplement to Methods to Estimate the Effect of Interventions on the Incidence and Transmission of TuberculosisR01GM122876 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WHITE, LAURA FORSBERG · 2017 to 2021
$1.9M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
CDC HHSDivision of Microbiology and Infectious Diseases U01AI100805Intramural CDC HHS CC999999NIAID NIH HHS K24 AI114444NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI119037NIAID NIH HHS R01 AI124217NIAID NIH HHS U01 AI100805NIGMS NIH HHS R01 GM122876
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antitubercular AgentsLevofloxacinTuberculosis, Multidrug-ResistantAdultAnti-Bacterial AgentsDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMiddle AgedSouth AfricaSputumTreatment OutcomeAnti-Bacterial AgentsAntitubercular AgentsLevofloxacindouble-blind randomized controlled triallevofloxacinMDR-TBTB

Identifiers

PMID40080768
PMCPMC12213226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.