Evidence map›Paper›PMID 40080690›Full record

ArticleSleep2025

A foundational transformer leveraging full night, multichannel sleep study data accurately classifies sleep stages.

Benjamin Fox, Joy Jiang, Sajila Wickramaratne, Patricia Kovatch, Mayte Suarez-Farinas, Neomi A Shah, Ankit Parekh, Girish N Nadkarni

Abstract read
In one paragraph

Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Artificial intelligence in sleep diagnostics for children under 2 years of age: state of the evidence and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Benjamin FoxThe Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5751-4884
Joy JiangThe Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sajila WickramaratneDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patricia KovatchDepartment of Scientific Computing, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mayte Suarez-FarinasCenter for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neomi A ShahDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ankit ParekhDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5396-0553
Girish N NadkarniThe Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
EPIDEMIOLOGY OF SLEEP-DISORDERED BREATHING IN ADULTSR01HL062252 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PEPPARD, PAUL E · 1999 to 2013
$14.1M
APPLES: Apnea Positive Pressure Long-Term Efficacy StudyU01HL068060 · NHLBI · STANFORD UNIVERSITY · PI KUSHIDA, CLETE A · 2002 to 2007
$14.1M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
DATA COORDINATING CENTER FOR SLEEP HEART STUDYU01HL064360 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DIENER-WEST, MARIE · 1999 to 2007
$4.4M
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6 · The paper itself

Abstract

STUDY

objectivesTo evaluate whether a foundational transformer using 8-hour, multichannel polysomnogram (PSG) data can effectively encode signals and classify sleep stages with state-of-the-art performance.

methodsThe Sleep Heart Health Study, Wisconsin Sleep Cohort, and Osteoporotic Fractures in Men (MrOS) Study visit 1 were used for training, and the Multi-Ethnic Study of Atherosclerosis (MESA), Apnea Positive Pressure Long-term Efficacy Study (APPLES), and MrOS visit 2 served as independent test sets. We developed PFTSleep, a self-supervised foundational transformer that encodes full-night sleep studies with brain, movement, cardiac, oxygen, and respiratory channels. These representations were used to train another model to classify sleep stages. We compared our results to existing methods, examined differences in performance by varying channel input data and training dataset size, and investigated an AI explainability tool to analyze decision processes.

resultsPFTSleep was trained with 13 888 sleep studies and tested on 4169 independent studies. Cohen's Kappa scores were 0.81 for our held-out set, 0.59 for APPLES, 0.60 for MESA, and 0.75 for MrOS Visit 2. Performance increases to 0.76 on a held-out MESA set when MESA is included in the training of the classifier head but not the transformer. Compared to other state-of-the-art AI models, our model shows high performance across diverse datasets while only using task-agnostic PSG representations from a foundational transformer as input for sleep stage classification.

conclusionsFull night, multichannel PSG representations from a foundational transformer enable accurate sleep stage classification comparable to state-of-the-art AI methods across diverse datasets.

Indexed as

PolysomnographySleep StagesAgedFemaleHumansMaleMiddle Ageddeep learningfoundational modelpolysomnographyself-supervisionsleep stage analysistransformer

Identifiers

PMID40080690
PMCPMC12663716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.