ArticleThe Journal of infectious diseases2025
Population-Based Estimates of Hepatitis E Virus-Associated Mortality in Bangladesh.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hepatitis E in Thailand: From Seroprevalence to Foodborne and Transfusion-Associated Risks.Journal of clinical medicine · 2026Review
- Acute liver failure induced by hepatitis E virus complicated with pancreatitis and refractory acute respiratory distress syndrome after rapid ascent to high altitude: a case report and literature review.Frontiers in physiology · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundHepatitis E virus (HEV) is endemic in many resource-poor countries. Despite an available vaccine, data on HEV-associated mortality are scarce, hindering informed decisions. This study aims to estimate the population-based rate of HEV-specific mortality in Bangladesh.
methodsDuring December 2014 to September 2017, we conducted surveillance in 6 tertiary hospitals in Bangladesh. Patients aged ≥14 years with acute jaundice were recruited, tested for IgM anti-HEV, and followed up postdischarge. A mortality survey in the hospital catchment areas identified deaths associated with acute jaundice, including maternal deaths, stillbirths, and neonatal deaths delivered by a mother with acute jaundice during pregnancy, as confirmed by 2 independent physicians reviewing verbal autopsy data.
resultsOut of 1925 patients with acute jaundice enrolled in the surveillance hospitals, 302 died, with 28 (9%) testing positive for IgM anti-HEV. In the hospital catchment areas, the team identified 587 jaundice-associated deaths, including 25 maternal deaths. Combining hospital-based surveillance and mortality survey data, the study estimated 986 (95% CI, 599-1338) HEV-associated deaths annually among individuals aged ≥14 years in Bangladesh, including 163 (95% CI, 57-395) maternal deaths. Additionally, 279 (95% CI, 101-664) stillbirths and 780 (95% CI, 365-1297) neonatal deaths were attributed to HEV infection annually.
conclusionsPrior Global Burden of Disease studies presented wildly varying modeling estimates of HEV-associated annual deaths, ranging from 50 000 in 2013 to 1932 in 2019. This study is the first to directly measure population-based estimates of mortality in Bangladesh, which can be used to determine the cost-effectiveness of hepatitis E vaccination and other interventions.
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