Evidence map›Paper›PMID 40080582›Full record

ArticleScience (New York, N.Y.)2025

Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms.

Xian Xia, Michelle M Shimogawa, Hui Wang, Samuel Liu, Angeline Wijono, Gerasimos Langousis, Ahmad M Kassem, James A Wohlschlegel, Kent L Hill, Z Hong Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Microtubule inner proteins in apicomplexan parasites.Biochemical Society transactions · 2026
    Review
  5. Article
  6. Article
  7. Axonemal dynein contributions to flagellar beat types and waveforms.bioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Article
  10. Heterogeneity of radial spoke components in Tetrahymena cilia.Cellular and molecular life sciences : CMLS · 2025
    Article
  11. CryoEM structure of thebioRxiv : the preprint server for biology · 2025
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xian XiaDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0001-9833-5017
Michelle M ShimogawaDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0001-6359-6006
Hui WangDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0002-9922-7170
Samuel LiuDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0009-0004-0176-3066
Angeline WijonoDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Gerasimos LangousisDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0002-0367-0304
Ahmad M KassemDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.ORCID 0000-0003-3399-901X
Kent L HillDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0001-6529-1273
Z Hong ZhouDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID 0000-0002-8373-4717

Funding

Biochemical and Functional Analysis of TrypaninR01AI052348 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HILL, KENT L · 2002 to 2023
$7.4M
High-Resolution CryoEM Reconstruction of Large ComplexesR01GM071940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, Z HONG · 2006 to 2025
$5.0M
Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass SpectrometryR35GM153408 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Akira Wohlschlegel · 2024 to 2026
$1.2M
Direct Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598k
NIAID NIH HHS R01 AI052348NIGMS NIH HHS R01 GM071940NIGMS NIH HHS R35 GM153408NIH HHS S10 OD018111
6 · The paper itself

Abstract

The flagellum of

Indexed as

Axonemal DyneinsAxonemeFlagellaProtozoan ProteinsTrypanosoma brucei bruceiCryoelectron MicroscopyModels, MolecularAxonemal DyneinsProtozoan Proteins

Identifiers

PMID40080582
PMCPMC12165780

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.