Evidence map›Paper›PMID 40080577›Full record

ArticleScience (New York, N.Y.)2025

Evolutionary adaptations of doublet microtubules in trypanosomatid parasites.

Matthew H Doran, Qingwei Niu, Jianwei Zeng, Tom Beneke, James Smith, Peter Ren, Sophia Fochler, Adrian Coscia, Johanna L Höög, Shimi Meleppattu and 5 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Microtubule inner proteins in apicomplexan parasites.Biochemical Society transactions · 2026
    Review
  5. Axonemal dynein contributions to flagellar beat types and waveforms.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. CryoEM structure of thebioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matthew H Doran *Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5224-4133
Qingwei Niu *Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7657-1462
Jianwei ZengDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6880-3366
Tom BenekeSir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID 0000-0001-9117-2649
James SmithSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Peter RenDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5283-3694
Sophia FochlerInstitute of Cell Biology, University of Bern, Bern, Switzerland.ORCID 0009-0002-4508-1951
Adrian CosciaDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6836-9993
Johanna L HöögDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Shimi MeleppattuDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3929-9997
Polina V LishkoDepartment of Cell Biology and Physiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3140-2769
Richard J WheelerMedawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4270-8360
Eva GluenzSir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID 0000-0003-4346-8896
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3159-9565
Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0021-0476

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Structure and Function of the Conoid in ToxoplasmaR01AI179885 · NIAID · WASHINGTON UNIVERSITY · PI L. David Sibley, Rui Zhang · 2024 to 2026
$2.2M
Mechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1M
Structural and functional studies of axonemal microtubule inner proteins (MIPs)R01GM138854 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, RUI · 2020 to 2024
$2.0M
Structural characterization of single, double and triple-headed axonemal dyneinsR01GM143183 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2022 to 2025
$1.4M
Medical Research Council MR/R000859/1NIAID NIH HHS R01 AI179885NIGMS NIH HHS R01 GM138854NIGMS NIH HHS R01 GM141109NIGMS NIH HHS R01 GM143183NIGMS NIH HHS T32 GM144273Wellcome Trust 211075
6 · The paper itself

Abstract

The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet microtubules (DMTs). In this work, we present cryo-electron microscopy structures of DMTs from two trypanosomatid species,

Indexed as

AxonemeBiological EvolutionCrithidiaDyneinsLeishmaniaProtozoan ProteinsCryoelectron MicroscopyFlagellaGene Knockout TechniquesDyneinsProtozoan Proteins

Identifiers

PMID40080577
PMCPMC7617938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.