Evidence map›Paper›PMID 40080450›Full record

ArticleACS sensors2025

Poly(3,4-ethylenedioxythiophene) Nanorod Arrays-Based Organic Electrochemical Transistor for SARS-CoV-2 Spike Protein Detection in Artificial Saliva.

Syed Atif Ali, Ying-Lin Chen, Hsueh-Sheng Tseng, Hailemichael Ayalew, Jia-Wei She, Bhaskarchand Gautam, Hsiung-Lin Tu, Yu-Sheng Hsiao, Hsiao-Hua Yu

Abstract read
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In one paragraph

Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Syed Atif AliDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.ORCID 0000-0002-8779-547X
Ying-Lin ChenDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.
Hsueh-Sheng TsengDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.
Hailemichael AyalewSmart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Jia-Wei SheSmart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Bhaskarchand GautamDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Hsiung-Lin TuInstitute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.ORCID 0000-0003-1125-1879
Yu-Sheng HsiaoDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.ORCID 0000-0003-2072-1844
Hsiao-Hua YuSmart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.ORCID 0000-0002-3603-6932

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outbreak and continued spread of coronavirus disease 2019 (COVID-19) have significantly threatened public health. Antibody testing is essential for infection diagnosis, seroepidemiological analysis, and vaccine evaluation. However, achieving convenient, fast, and accurate detection remains challenging in this prolonged battle. This study reports a highly sensitive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein detection platform based on organic electrochemical transistors (OECTs) for biosensing applications. We developed a nanostructured poly(3,4-ethylenedioxythiophene) (PEDOT) conductive polymer with the carboxylic acid functional group (PEDOTAc) for modifying specific antibodies on an OECT channel for the detection of the COVID-19 spike protein. The OECT device features a channel composed of a PEDOT:polystyrenesulfonate (PEDOT:PSS) bottom layer, with the upper layer decorated with PEDOTAc nanorod arrays via the oxidative polymerization and a trans-printing method. Our novel PEDOTAc nanorod array-based OECT device exhibits promising potential for future healthcare and point-of-care sensing due to its rapid response, high sensitivity, and high accuracy. Through optimization, we achieved specific detection of the SARS-CoV-2 spike protein within minutes, with a detectable region from 10 fM to 100 nM. These biosensors hold significant promise for use in the diagnosis and prognosis of COVID-19.

Indexed as

Biosensing TechniquesBridged Bicyclo Compounds, HeterocyclicCOVID-19Electrochemical TechniquesNanotubesPolymersSalivaSARS-CoV-2Spike Glycoprotein, CoronavirusTransistors, ElectronicHumansLimit of DetectionBridged Bicyclo Compounds, Heterocyclicpoly(3,4-ethylene dioxythiophene)PolymersSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2biosensorcoronavirus disease 2019 (COVID-19)organic electrochemical transistors (OECTs)poly(3,4-ethylenedioxythiophene) (PEDOT)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID40080450
PMCPMC11959606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.