Evidence map›Paper›PMID 40080404›Full record

ArticleAnnals of clinical and translational neurology2025

Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability.

Nicole Shelley, Bradley Judge, Dmitriy A Yablonskiy, Robert T Naismith, Matthew R Brier, Anne H Cross

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicole ShelleyDepartment of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.ORCID 0009-0003-9607-9840
Bradley JudgeDepartment of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.
Dmitriy A YablonskiyDepartment of Radiology, Washington University in St. Louis, Saint Louis, Missouri, USA.
Robert T NaismithDepartment of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.
Matthew R BrierDepartment of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.ORCID 0000-0001-5987-8705
Anne H CrossDepartment of Neurology, Washington University in St. Louis, Saint Louis, Missouri, USA.ORCID 0000-0003-0829-7569

Funding

In vivo MRI Biomarkers of Microstructural Correlates of Brain Pathology in Preclinical and Early Alzheimer DiseaseR01AG054513 · NIA · WASHINGTON UNIVERSITY · PI YABLONSKIY, DMITRIY A · 2017 to 2021
$2.7M
In vivo Identification of Pre-Atrophic Brain Neurodegeneration in Prodromal Alzheimer Disease with Quantitative Gradient Recalled Echo MRIRF1AG077658 · NIA · WASHINGTON UNIVERSITY · PI YABLONSKIY, DMITRIY A · 2022 to 2022
$2.2M
Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer DiseaseRF1AG082030 · NIA · WASHINGTON UNIVERSITY · PI GOYAL, MANU S, YABLONSKIY, DMITRIY A · 2023 to 2023
$2.0M
In vivo Identification of Pre-Atrophic Brain Neurodegeneration in Prodromal Alzheimer Disease with Quantitative Gradient Recalled Echo MRIR01AG077658 · NIA · WASHINGTON UNIVERSITY · PI DMITRIY A YABLONSKIY · 2025 to 2026
$1.4M
PET and MRI Evaluation of Cerebral Inflammation and Metabolic Stress in Relapsing Multiple SclerosisK23NS128325 · NINDS · WASHINGTON UNIVERSITY · PI Matthew Ryan Brier · 2023 to 2026
$931k
Firestone FundLeon and Harriet Felman Human MS Research FundNIA NIH HHS R01 AG054513NIA NIH HHS R01 AG077658NIA NIH HHS RF1 AG077658NIA NIH HHS RF1 AG082030NINDS NIH HHS K23 NS128325The Manny & Rosalyn Rosenthal - Dr. John L. Trotter MS Center Chair in Neuroimmunology of the Foundation for Barnes-Jewish Hospital
6 · The paper itself

Abstract

objectiveThe claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS).

methodsThis study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific disability domains. We compared the impact of claustrum volume reductions on neurological disability versus the well-studied thalamus. Data from the 15,793 participants in the MS PATHS study were used for primary analyses. A second cohort of 71 people with MS and healthy controls from our center was used for validation.

resultsClaustrum and thalamic volumes were reduced to a similar degree across MS types. Claustrum volume, like thalamic volume, was associated with disability measures of walking speed, upper extremity dexterity, and cognition. Partial correlation analyses supported that both claustrum and thalamic volumes independently contribute to disability. Interestingly, claustrum volume outperformed thalamic volume as a predictor of future disability progression.

interpretationThis study suggests that damage and resulting atrophy to the claustrum may be an important component of MS-related disability.

Indexed as

ClaustrumMultiple SclerosisThalamusAdultAtrophyDisability EvaluationDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedclaustrumdisabilitymagnetic resonance imagingmultiple sclerosisthalamus

Identifiers

PMID40080404
PMCPMC12172115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.