Evidence map›Paper›PMID 40080319›Full record

ArticleNatural products and bioprospecting2025

Asprecosides A-J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella.

Yuwei Wu, Baihui Zhang, Wenxian Li, Lihua Peng, Weilin Qiao, Wei Li, De-An Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuwei WuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Baihui ZhangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Wenxian LiZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, People's Republic of China.
Lihua PengZhongshan Zhongzhi Pharmaceutical Group Co. Ltd., Zhongshan, 528400, People's Republic of China.
Weilin QiaoZhongshan Zhongzhi Pharmaceutical Group Co. Ltd., Zhongshan, 528400, People's Republic of China.
Wei LiSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China. liwei1@simm.ac.cn.
De-An GuoSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China. daguo@simm.ac.cn.

Funding

Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine 2020
6 · The paper itself

Abstract

Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1-9) and one oleanane-type glycoside (10), along with seven known compounds (11-17). Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds 7, 12, 15, and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.

Indexed as

Cytotoxic activityIlex asprellaOleananePentacyclic triterpenoid glycosideUrsane

Identifiers

PMID40080319
PMCPMC11906957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.