Evidence map›Paper›PMID 40080231›Full record

ArticleDiscover nano2025

Comparative toxicity and environmental impact assessments of sonochemically-synthesized CuO and Zn-doped CuO nanoparticles using zebrafish and LCA tools.

Beatrice Negrini, Pamela Floris, Christian D'Abramo, Seyed Ahmad Aldaghi, Mattia Costamagna, Massimo Perucca, Melissa Saibene, Ilana Perelshtein, Anita Colombo, Patrizia Bonfanti and 1 more

Abstract read
In one paragraph

Article in Discover nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Beatrice Negrini *Department of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy. b.negrini1@campus.unimib.it.ORCID http://orcid.org/0000-0003-3810-756X
Pamela Floris *Department of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy.ORCID http://orcid.org/0000-0001-9813-985X
Christian D'AbramoDepartment of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy.ORCID http://orcid.org/0009-0008-6558-9449
Seyed Ahmad AldaghiProject Hub360, Avigliana-Metropolitan City of Turin, Italy.ORCID http://orcid.org/0009-0000-0084-9109
Mattia CostamagnaProject Hub360, Avigliana-Metropolitan City of Turin, Italy.ORCID http://orcid.org/0000-0002-0378-8011
Massimo PeruccaProject Hub360, Avigliana-Metropolitan City of Turin, Italy.ORCID http://orcid.org/0000-0002-8399-9643
Melissa SaibeneDepartment of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy.ORCID http://orcid.org/0000-0003-4765-6974
Ilana PerelshteinDepartment of Chemistry and Nanomaterials, Bar-Ilan University Center for Advanced Materials and Nanotechnology, Ramat-Gan, Israel.ORCID http://orcid.org/0000-0003-1944-451X
Anita ColomboDepartment of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy.ORCID http://orcid.org/0000-0001-8444-495X
Patrizia BonfantiDepartment of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy. patrizia.bonfanti@unimib.it.ORCID http://orcid.org/0000-0003-0827-5298
Paride ManteccaDepartment of Earth and Environmental Sciences, Research Centre POLARIS (Environmental Health & Sustainability), University of Milano Bicocca, Milan, Italy.ORCID http://orcid.org/0000-0002-6962-049X

Funding

EU and Italian MUR 869178
6 · The paper itself

Abstract

Nanomaterials (NMs), including nanoparticles (NPs), offer promising potential in achieving the European Commission's Green Deal goals of climate-neutral, zero-pollution and circular economy. Metal oxide NPs display antimicrobial properties, with efficacy also towards antimicrobial-resistant bacteria. Nevertheless, the increasing manufacture, use and unintended release of NMs particularly in aquatic compartments, raises concerns about their environmental sustainability and safety towards non-target organisms. Within the Safe and Sustainable by Design framework, this study compares toxicity and environmental impacts of sonochemically synthesized water-based CuO and Zn-doped CuO NPs. Zebrafish embryos were exploited in a high-throughput developmental and behavioral screening to investigate nanosafety. The Fish Embryo acute Toxicity test was used to assess the NPs aquatic toxicity potential, while behaviour was addressed by tracking embryos activity. The Life Cycle Assessment (LCA) methodology was implemented through the OpenLCA software to evaluate the environmental footprint of the NPs synthesis. Our findings showed no significative lethality at the tested concentrations (0.01-100 mg/L) (LC

Identifiers

PMID40080231
PMCPMC11906939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.