Evidence map›Paper›PMID 40080161›Full record

ArticleMikrochimica acta2025

A multifunctional Pt/DMSN nanozyme-based colorimetric-fluorescence sensing platform for breast cancer detection.

Xinrui Xue, Fang Zheng, Yujia Luo, Wenyu Chen, Yuanyuan Gao, Kun Wei

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinrui XueSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Fang ZhengSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Yujia LuoSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Wenyu ChenSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Yuanyuan GaoSichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, 637000, Sichuan, P. R. China. 594871494@qq.com.
Kun WeiSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China. weikun@scut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanozyme-linked immunosorbent assay has emerged as a promising strategy for sensitive biosensing. However, the catalytic activity and stability of nanozymes affect the accuracy of immunosorbent assays. In this study, we synthesized a Pt/DMSN nanozyme with peroxidase-mimicking activity, which effectively catalyzed the oxidation of peroxidase substrate 3,3',5,5'-tetramethylbenzidin (TMB) in the presence of hydrogen peroxide. Capitalizing on its peroxidase-like activity, the Pt/DMSN nanozyme was functionalized with dual-fluorescent recognition elements (HER2-mAbs and sk6Ea aptamers) to establish a nanozyme-linked immunosorbent assay platform, which exhibited catalytic stability and substrate affinity comparable to horseradish peroxidase. The resulting Multi-Pt/DMSN platform was used to selectively distinguish HER2-positive breast cancer cells from luminal A, triple-negative breast cancer subtypes, and non-neoplastic cells, achieving a detection limit of 50 HER2-positive cells within 30 min. The combination of robust enzyme-like activity and tumor-targeting properties enables fluorescence imaging, providing dual-mode diagnostic functionality. This work presents a prospective platform for differentiating breast cancer subtypes in early diagnosis.

Indexed as

Breast NeoplasmsColorimetryMetal NanoparticlesPlatinumAptamers, NucleotideBenzidinesBiosensing TechniquesCatalysisCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleFluorescent DyesHumansHydrogen PeroxideLimit of Detection3,3',5,5'-tetramethylbenzidineAptamers, NucleotideBenzidinesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesFluorescent DyesHydrogen PeroxidePlatinumBreast cancer differentiationColorimetric assayFluorescence imagingNanozymePeroxidase mimic

Identifiers

PMID40080161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.