Evidence map›Paper›PMID 40080151›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Neuroprotection in traumatic brain injury: effects of alpha-asarone and Acorus calamus extract in mice using weight drop model.

Sunishtha Kalra, Himanshu Sachdeva, Aditya Bhushan Pant, Govind Singh

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sunishtha KalraDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Himanshu SachdevaDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Aditya Bhushan PantIndian Institute of Toxicological Research, Council of Scientific and Industrial Research, Lucknow, Uttar Pradesh, 226001, India.
Govind SinghDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India. drgovind.pharma@mdurohtak.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a significant public health concern characterized by severe neurological consequences. The management of TBI remains a formidable challenge, necessitating a multifaceted approach aimed at reducing secondary injury and promoting neuroprotection. This study assessed the neuroprotective potential of Alpha-asarone (AA) at 12.5, 25, 50 mg/kg, p.o (phytoconstituent of Acorus calamus) at, and Acorus calamus (AC) extract at 190 mg/kg, p.o in a murine TBI model induced by weight drop method. Blood-Brain Barrier (BBB) permeability and oxidative stress were evaluated on 1

Indexed as

AcorusAnisolesBrain Injuries, TraumaticNeuroprotective AgentsPlant ExtractsAllylbenzene DerivativesAnimalsBlood-Brain BarrierBrainDisease Models, AnimalDose-Response Relationship, DrugMaleMiceOxidative StressAllylbenzene DerivativesAnisolesasaroneNeuroprotective AgentsPlant ExtractsAcorus calamusAlpha asaroneBlood–Brain BarrierNeurological Severity ScoreOxidative stressTraumatic brain injury

Identifiers

PMID40080151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.