Ratiometric fluorescence quantification of folic acid utilizing D-penicillamine-based carbon dots in conjunction with glutathione S-transferase-Au nanoclusters.

Mengyan Zhou, Zhihui Zhang, Qi Zheng, Mingdi Yu, Mengxu Si, Sirui Wu, Yanan Zhang, Shushu Ding, Ding-Yi Fu

Abstract read

In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengyan ZhouNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Zhihui ZhangNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Qi ZhengNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Mingdi YuNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Mengxu SiNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Sirui WuNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Yanan ZhangNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China.

Shushu DingNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China. ssding@ntu.edu.cn.

Ding-Yi FuNantong Key Laboratory of Small Molecular Drug Innovation, School of Pharmacy, Nantong University, Nantong, 226001, China. fudingyi@ntu.edu.cn.

Funding

Large Instruments Open Foundation of Nantong University KFJN2465Nantong University Students' innovation and entrepreneurship training program 2024278Natural Science Foundation of the Jiangsu Higher Education Institutions of China 24KJD150004Natural Science Fund of Jiangsu Province in China BK20200972Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX24_2075

6 · The paper itself

Abstract

A novel ratiometric fluorescent nanohybrid probe was constructed for sensitive and selective determination of folic acid (FA) based on blue D-penicillamine-based carbon dots (CDs) and red glutathione S-transferase-Au nanoclusters (GST-AuNCs). Upon the excitation of 380 nm, the obtained CDs-NCs possessed two distinct emission peaks at 465 and 665 nm. The fluorescence intensity at 465 nm was incrementally enhanced with the addition of FA attributed to the hydrogen bonds formation, while the fluorescence intensity at 665 nm was quenched caused by the electronic interaction and the inner filter effects. The fluorescence intensity ratio (I

Indexed as

Fluorescent DyesFolic AcidGlutathione TransferaseMetal NanoparticlesPenicillamineQuantum DotsCarbonGoldHeLa CellsHumansLimit of DetectionSpectrometry, FluorescenceCarbonFluorescent DyesFolic AcidGlutathione TransferaseGoldPenicillamineBioimagingCarbon dotsFolic acidGold nanoclustersIntracellular folic acid detectionRatiometric fluorescence probe

Identifiers

PMID40080078

DOI10.1007/s00604-025-07062-8

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.