Evidence map›Paper›PMID 40080062›Full record

ArticleeLife2025

Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity.

Shihui Chen, Carolyn Marie Phillips

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shihui ChenDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0009-0006-3036-5475
Carolyn Marie PhillipsDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0002-6228-6468

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of gene expression and genome organization by small RNAsR35GM119656 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Carolyn Marie Phillips · 2016 to 2026
$5.3M
NCI NIH HHS P30 CA014089NIGMS NIH HHS R35 GM119656NIH HHS P40 OD010440
6 · The paper itself

Abstract

RNA interference (RNAi) is a conserved pathway that utilizes Argonaute proteins and their associated small RNAs to exert gene regulatory function on complementary transcripts. While the majority of germline-expressed RNAi proteins reside in perinuclear germ granules, it is unknown whether and how RNAi pathways are spatially organized in other cell types. Here, we find that the small RNA biogenesis machinery is spatially and temporally organized during

Indexed as

Argonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalRNA-Binding ProteinsAnimalsRNA InterferenceArgonaute ProteinsCaenorhabditis elegans ProteinsNRDE-3 protein, C elegansRNA-Binding ProteinsargonauteC. eleganschromosomesgene expressionsmall RNAs

Identifiers

PMID40080062
PMCPMC11906161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.