Evidence map›Paper›PMID 40079756›Full record

ArticleAnnals of medicine2025

Prevalence of extracranial carotid artery disease in symptomatic peripheral artery disease and implications for long-term outcome.

Bernhard Zierfuss, Ladislaja Witt-Dörring, Anna Ceschi A Santa Croce, Antonia Hannes, Moritz Staudacher, Gerfried Pesau, Oliver Schlager, Michael Gschwandtner, Gerit-Holger Schernthaner, Clemens Höbaus

Abstract read
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernhard ZierfussDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Ladislaja Witt-DörringDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Anna Ceschi A Santa CroceDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Antonia HannesDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Moritz StaudacherDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Gerfried PesauDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Oliver SchlagerDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Michael GschwandtnerDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Gerit-Holger SchernthanerDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.
Clemens HöbausDivision of Angiology, Department of Medicine 2, Medical University of Vienna, Austria.ORCID 0000-0002-9704-1452

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with peripheral artery disease (PAD) still experience excessive rates of fatal cardiovascular events. In this context, the relevance of co-existing extracranial carotid artery disease (ECAD) on outcome in patients with PAD is unclear. Thus, this study elucidates long-term outcome effects of the presence of both atherosclerotic entities for further risk stratification. MATERIALS AND

methodsA total of 669 patients from the Lip-LEAD study with symptomatic PAD (Fontaine stage 2-4) were evaluated for ECAD (internal carotid artery stenosis >50%) with ultrasonography within 6 months after endovascular repair for PAD. Outcome was assessed with a long-term follow-up period with a maximum of 10 years.

resultsPatients presenting with ECAD (

conclusionPatients with additional ECAD to symptomatic PAD exhibited an unfavourable long-term outcome in comparison to those without. The results suggest that the additional presence of ECAD highlights a highly vulnerable cohort of patients with symptomatic PAD at risk for further fatal CV events and thus should be considered for further diagnostic evaluation and stronger risk modification initiatives.

Indexed as

Carotid Artery DiseasesCarotid StenosisPeripheral Arterial DiseaseAgedAnkle Brachial IndexFemaleFollow-Up StudiesHumansMaleMiddle AgedPrevalenceRisk FactorsTreatment OutcomeUltrasonographycarotid artery stenosismortalityPADpolyvascular disease

Identifiers

PMID40079756
PMCPMC11912231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.