Evidence map›Paper›PMID 40079484›Full record

ArticleMagnetic resonance in medicine2025

Parallel detection of MRI and

Robin A de Graaf, Monique Thomas, Henk M De Feyter

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robin A de GraafMagnetic Resonance Research Center (MRRC), Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-6570-7010
Monique ThomasMagnetic Resonance Research Center (MRRC), Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Henk M De FeyterMagnetic Resonance Research Center (MRRC), Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-6111-0316

Funding

Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
Validation of imaging brain tumor metabolism using deuterated glucoseR01EB033764 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2023 to 2026
$2.4M
Time-efficient MRI and deuterium metabolic imaging (DMI) through parallel signal acquisitionR01EB034730 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF · 2024 to 2026
$1.4M
Single-scan, multi-contrast imaging of glucose metabolism in patients with glioblastomaR01CA288833 · NCI · YALE UNIVERSITY · PI Henk De Feyter · 2025 to 2026
$1.4M
Mapping of choline uptake and metabolism in brain tumors with deuterium metabolic imaging (DMI)R03CA267438 · NCI · YALE UNIVERSITY · PI DE FEYTER, HENK · 2023 to 2024
$168k
American Brain Tumor AssociationNCI NIH HHS R01 CA288833NCI NIH HHS R03 CA267438NIBIB NIH HHS R01 EB025840NIBIB NIH HHS R01 EB033764NIBIB NIH HHS R01 EB034730NIH/NCI R01-CA288833NIH/NCI R03-CA267438NIH/NIBIB R01-EB025840NIH/NIBIB R01-EB033764NIH/NIBIB R01-EB034730
6 · The paper itself

Abstract

purposeMRI and MRSI provide unique and complementary information on anatomy, structure, function, and metabolism. The default strategy for a combined MRI and MRSI study is a sequential acquisition of both modalities, leading to long scan times. As MRI and MRSI primarily detect water and metabolites, respectively, the small frequency difference between resonances can be exploited with frequency-selective RF pulses to achieve interleaved or parallel detection of MRI and MRSI, without an increase in total scan time.

methodsHere, we describe the pulse sequence modifications necessary to allow acquisition of T

resultsPhantom experiments demonstrated artifact-free 3D MRIs. MRSIs in the absence or presence of MRI elements were identical in sensitivity and spectral resolution (line width) and showed consistent water suppression. Parallel MRI-MRSI was applied to the brains of tumor-bearing rats in vivo. High-contrast, high-sensitivity metabolic MRSI data at 8 μL nominal resolution was acquired in parallel with 3D T

conclusionMulti-contrast MRIs and MRSI can be acquired in parallel by utilizing the small frequency difference between water and metabolites. This opens the possibility for shorter overall scans times, or the acquisition of higher-resolution or additional contrast MRIs.

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingProton Magnetic Resonance SpectroscopyAlgorithmsAnimalsImaging, Three-DimensionalPhantoms, ImagingRatsfrequency‐selective excitationMRIMRSIparallel acquisition

Identifiers

PMID40079484
PMCPMC12140887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.