Evidence map›Paper›PMID 40079425›Full record

ArticleJournal of applied clinical medical physics2025

Dosimetric effect of silicone-based gel on skin surface during volumetric modulated arc therapy for breast cancer.

Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama and 4 more

Abstract read
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In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tenyoh SuzukiDepartment of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan.
Shingo OhiraDepartment of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan.
Mami OgitaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Takeshi OhtaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Yuki NozawaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Masanari MinamitaniDepartment of Comprehensive Radiation Oncology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Takuya HayashiDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Shigeki SaegusaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Toshikazu ImaeDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6850-3806
Tsuyoshi UeyamaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Atsuto KatanoDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Hideomi YamashitaDepartment of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Weishan ChangDepartment of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan.
Keiichi NakagawaDepartment of Comprehensive Radiation Oncology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.

methodsA VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON-Vs Ointment) having eight thicknesses (0.0-1.5 mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations-subclavicular, medial, and lateral aspects of the left breast.

resultsMean dose enhancement ratios (DERs) of 102%-116% were observed in VMAT for topical agent thicknesses of 0.1-0.5 mm, increasing to 116%-126% at 1.0 and 1.5 mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (p < 0.05).

conclusionsThis study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5 mm potentially exceeded the threshold dose for acute skin reactions.

Indexed as

Breast NeoplasmsPhantoms, ImagingRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedSilicone GelsSkinFemaleHumansOrgans at RiskRadiotherapy DosageSilicone Gelsbreast cancersilicone‐based gelskin surface doseStrataXRTvolumetric modulated arc therapy

Identifiers

PMID40079425
PMCPMC12148794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.