Evidence map›Paper›PMID 40079206›Full record

ArticleJournal of biophotonics2025

Optomechanical Properties of Swine Skin Tissue Treated With a Nontoxic Optical Clearing Agent.

Noemi Correa, Minji Suh, Abdul Mohizin, Jinu Sudhakaran, Kee Sung Lee, Jung Kyung Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Noemi CorreaSchool of Mechanical Engineering, Kookmin University, Seoul, Republic of Korea.
Minji SuhDepartment of Mechanical Systems Engineering, Graduate School, Kookmin University, Seoul, Republic of Korea.
Abdul MohizinBiosensor Group, KIST Europe, Saarbrucken, Germany.
Jinu SudhakaranDepartment of Mechanical Engineering, Graduate School, Kookmin University, Seoul, Republic of Korea.
Kee Sung LeeSchool of Mechanical Engineering, Kookmin University, Seoul, Republic of Korea.
Jung Kyung KimSchool of Mechanical Engineering, Kookmin University, Seoul, Republic of Korea.ORCID 0000-0002-4164-6655

Funding

National Research Foundation (NRF) NRF-2022R1A4A5018891National Research Foundation (NRF) RS-2023-00241885National Research Foundation of Korea
6 · The paper itself

Abstract

This study evaluated the optomechanical and structural properties of individual macroscopic layers in swine skin tissues treated with a nontoxic optical clearing agent. The clearing agent was prepared by dissolving 2,2'-thiodiethanol in a phosphate-buffered solution and applied for up to 6 days. Prolonged clearing increased both the total and unscattered transmittance. Peaks associated with deoxygenated hemoglobin, oxygenated hemoglobin, and water showed marked reduction with extended clearing times. Histopathological examination revealed no significant structural alterations. A clearing time of approximately 4-5 days is recommended for optimal imaging, as it minimizes changes in mechanical properties. These findings support the use of optical clearing in deep tissue imaging, particularly when preserving macroscopic mechanical properties is essential, despite the inherent limitation of sample opacity.

Indexed as

Mechanical PhenomenaOptical PhenomenaSkinAnimalsBiomechanical PhenomenaSwinedeep tissue imagingindentation testspectrophotometrytissue optical clearingtissue optics

Identifiers

PMID40079206
PMCPMC12318643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.